학술논문
Tissue-resident memory T cells in immune-related adverse events: friend or foe?
Document Type
Academic Journal
Author
Reschke R; Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA.; Department of Dermatology and Venerology and Fleur Hiege-Center for Skin Cancer Research, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.; Gajewski TF; Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA.; Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA.
Source
Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: eCollection Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE
Subject
Language
English
Abstract
Many cancer patients experience toxicity during checkpoint blockade immunotherapy, which often leads to treatment discontinuation. To this end, understanding the mechanisms mediating immune-related adverse events (irAE) should ultimately enable improvement in clinical outcomes. Recent work has revealed that tissue-resident memory T (T RM ) cells are locally expanded in irAE-dermatitis and -colitis.
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.)
Competing Interests: No potential conflict of interest was reported by the author(s).
(© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.)