학술논문
Statins and the risk of pancreatic cancer: A systematic review and meta-analysis of 2,797,186 patients.
Document Type
Academic Journal
Author
Karbowska E; Department of CT and MR Radiology, Maria Sklodowska-Curie Bialystok Oncology Center, Bialystok, Poland.; Swieczkowski D; Department of Toxicology, Faculty of Pharmacy, Medical University of Gdansk, Gdańsk, Poland.; Gasecka A; First Chair and Department of Cardiology, Medical University of Warsaw, Poland.; Pruc M; Research Unit, Polish Soceity of Disaster Medicine, Warsaw, Poland.; Safiejko K; Colorectal Cancer Unit, Maria Sklodowska-Curie Bialystok Oncology Center, Bialystok, Poland.; Ladny JR; Department of Emergency Medicine, Medical University of Bialystok, Bialystok, Poland.; Kopiec T; First Chair and Department of Cardiology, Medical University of Warsaw, Poland.; Jaguszewski MJ; 1st Department of Cardiology, Medical University of Gdansk, Gdansk, Poland.; Filipiak KJ; Institute of Clinical Science, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland.; Rafique Z; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA.; Szarpak L; Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland. lukasz.szarpak@gmail.com.; Research Unit, Maria Sklodowska-Curie Bialystok Oncology Center, Bialystok, Poland. lukasz.szarpak@gmail.com.; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA;. lukasz.szarpak@gmail.com.
Source
Publisher: Via Medica Country of Publication: Poland NLM ID: 101392712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1898-018X (Electronic) Linking ISSN: 1898018X NLM ISO Abbreviation: Cardiol J Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Statin use in many studies is related to the improvement of a patients' condition including reducing the risk of various malignancies. Herein, is a systematic review and meta-analysis to examine the evidence on the association between statin therapy and the risk of the occurrence of pancreatic cancer, mainly in terms of decreased risk of developing pancreatic cancer among patients using statin therapy in the long-term perspective.
Methods: PubMed, Web of Science, Scopus and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from database inception to December 1st, 2021. Random effect models were used to estimate summary odds ratios (OR) and the corresponding 95% confidence intervals (CI).
Results: A total of 26 studies comprising 2,797,186 patients were included. Polled analysis showed that pancreatic cancer occurrence in statin vs. no-statin group varied and amounted to 0.4% vs. 0.6% (RR = 0.83; 95% CI: 0.72-0.96; I² = 84%; p = 0.01).
Conclusions: In summary, the present analysis shows that overall statins use is significantly associated with a reduction in risk of pancreatic cancer. However, these results were not confirmed for the randomized controlled trial subgroup. Further prospective studies are needed to confirm the current results.
Methods: PubMed, Web of Science, Scopus and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from database inception to December 1st, 2021. Random effect models were used to estimate summary odds ratios (OR) and the corresponding 95% confidence intervals (CI).
Results: A total of 26 studies comprising 2,797,186 patients were included. Polled analysis showed that pancreatic cancer occurrence in statin vs. no-statin group varied and amounted to 0.4% vs. 0.6% (RR = 0.83; 95% CI: 0.72-0.96; I² = 84%; p = 0.01).
Conclusions: In summary, the present analysis shows that overall statins use is significantly associated with a reduction in risk of pancreatic cancer. However, these results were not confirmed for the randomized controlled trial subgroup. Further prospective studies are needed to confirm the current results.