학술논문
The Effect of Sedation on Diagnostic Lumbar Medial Branch Blocks for Facetogenic Low Back Pain: An Observational Study.
Document Type
Academic Journal
Author
Patel N; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI.; Nowak K; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI; Wayne State University School of Medicine, Detroit, MI.; Vaidyanathan A; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI.; Milad H; Wayne State University School of Medicine, Detroit, MI.; Adlaka K; Wayne State University School of Medicine, Detroit, MI.; Rubino C; Wayne State University School of Medicine, Detroit, MI.; Vasquez ET; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI.; Nerusu L; Deparment of Anesthesiology, Ohio State University, Columbus, OH.; Rahavard B; Synovation Medical Group, Rancho Mirage, CA.; Fayed M; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI.; Forrest P; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI; Wayne State University School of Medicine, Detroit, MI.; Money S; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI; Wayne State University School of Medicine, Detroit, MI.; Dwivedi S; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI; Wayne State University School of Medicine, Detroit, MI.; Zador L; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI; Wayne State University School of Medicine, Detroit, MI.; Haddad R; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI; Wayne State University School of Medicine, Detroit, MI.; Khaja D; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI; Wayne State University School of Medicine, Detroit, MI.; Sibai N; Department of Anesthesiology, Pain Management and Perioperative Medicine- Henry Ford Health System, Detroit, MI; Wayne State University School of Medicine, Detroit, MI.; Aiyer R; Integrative Sports and Spine, Irvine, CA.
Source
Publisher: American Society of Interventional Pain Physicians Country of Publication: United States NLM ID: 100954394 Publication Model: Print Cited Medium: Internet ISSN: 2150-1149 (Electronic) Linking ISSN: 15333159 NLM ISO Abbreviation: Pain Physician Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Lumbar medial branch blocks (MBB) are some of the most commonly performed pain procedures in the United States. Diagnostic MBBs are performed to confirm if the generator of low back pain is the facet joint. However, with diagnostic injections, false positive blocks may occur.
Objectives: Our prospective observational study aims to investigate the effects of midazolam sedation on patients' perceived intensity of pain relief following lumbar MBB.
Study Design: This is a single-center multi-site prospective observational study registered on clinicaltrials.gov (NCT04453449).
Setting: The study was approved by the Henry Ford Health System Institutional Review Board (IRB) in June 2020 (IRB# 14010) and registered on clinicaltrials.gov in July 2020 (NCT04453449). This manuscript adheres to the applicable EQUATOR STROBE guidelines for an observational cohort study.
Methods: Patients that underwent MBB without sedation were compared to sedated patients. Patients were asked to complete the Numeric Rating Scale (NRS) at baseline, one day after their diagnostic blocks, as well as 4 weeks and 8 weeks after their lumbar radiofrequency ablation (RFA). The primary outcome is the difference between baseline NRS pain scores and the lowest reported score in the 8 hours following MBB. For patients who proceed to RFA, the frequency of false positive blocks was evaluated. A patient was considered to have a false positive block when they failed to achieve 50% pain relief from RFA after 2 successful sequential MBBs.
Results: There was no significant difference in the NRS pain score change between the sedated and non-sedated groups for diagnostic block one (P = 0.167) and diagnostic block 2 (P = 0.6145). There was no significant difference of false positive rates between non-sedation and sedation patients at 4-weeks post-RFA (P = 0.7178) and at 8-weeks post-RFA (P = 1.000).
Limitations: Some of the limitations of this study include its nonrandomized design, patient self-reported pain scores, as well as the small variability in the injection technique of proceduralists and in the anatomical location of the injection site.
Conclusions: This study showed that midazolam did not change patients' perceived intensity of pain following MBB, as well as false positive rates after RFA. Larger studies are required to draw definitive conclusions.
Objectives: Our prospective observational study aims to investigate the effects of midazolam sedation on patients' perceived intensity of pain relief following lumbar MBB.
Study Design: This is a single-center multi-site prospective observational study registered on clinicaltrials.gov (NCT04453449).
Setting: The study was approved by the Henry Ford Health System Institutional Review Board (IRB) in June 2020 (IRB# 14010) and registered on clinicaltrials.gov in July 2020 (NCT04453449). This manuscript adheres to the applicable EQUATOR STROBE guidelines for an observational cohort study.
Methods: Patients that underwent MBB without sedation were compared to sedated patients. Patients were asked to complete the Numeric Rating Scale (NRS) at baseline, one day after their diagnostic blocks, as well as 4 weeks and 8 weeks after their lumbar radiofrequency ablation (RFA). The primary outcome is the difference between baseline NRS pain scores and the lowest reported score in the 8 hours following MBB. For patients who proceed to RFA, the frequency of false positive blocks was evaluated. A patient was considered to have a false positive block when they failed to achieve 50% pain relief from RFA after 2 successful sequential MBBs.
Results: There was no significant difference in the NRS pain score change between the sedated and non-sedated groups for diagnostic block one (P = 0.167) and diagnostic block 2 (P = 0.6145). There was no significant difference of false positive rates between non-sedation and sedation patients at 4-weeks post-RFA (P = 0.7178) and at 8-weeks post-RFA (P = 1.000).
Limitations: Some of the limitations of this study include its nonrandomized design, patient self-reported pain scores, as well as the small variability in the injection technique of proceduralists and in the anatomical location of the injection site.
Conclusions: This study showed that midazolam did not change patients' perceived intensity of pain following MBB, as well as false positive rates after RFA. Larger studies are required to draw definitive conclusions.