학술논문
Circulating Growth and Sex Hormone Levels and Breast Tissue Composition in Young Nulliparous Women.
Document Type
Academic Journal
Author
Denholm R; Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.; De Stavola BL; Population, Policy and Practice Programme, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.; Hipwell JH; Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, UCL, London, United Kingdom.; Doran SJ; Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.; Holly JMP; IGFs & Metabolic Endocrinology Group, School of Translational Health Sciences, Faculty of Health Sciences, University of Bristol, Bristol, United Kingdom.; Folkerd E; The Ralph Lauren Centre for Breast Cancer Research, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom.; Dowsett M; The Ralph Lauren Centre for Breast Cancer Research, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom.; Leach MO; Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.; Hawkes DJ; Centre for Medical Image Computing, Department of Medical Physics and Bioengineering, UCL, London, United Kingdom.; Dos-Santos-Silva I; Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. isabel.silva@lshtm.ac.uk.
Source
Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9200608 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7755 (Electronic) Linking ISSN: 10559965 NLM ISO Abbreviation: Cancer Epidemiol Biomarkers Prev Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Endogenous hormones are associated with breast cancer risk, but little is known about their role on breast tissue composition, a strong risk predictor. This study aims to investigate the relationship between growth and sex hormone levels and breast tissue composition in young nulliparous women.
Methods: A cross-sectional study of 415 young (age ∼21.5 years) nulliparous women from an English prebirth cohort underwent a MRI examination of their breasts to estimate percent-water (a proxy for mammographic percent density) and provided a blood sample to measure plasma levels of growth factors (insulin-like growth factor-I, insulin-like growth factor-II, insulin growth factor-binding protein-3, growth hormone) and, if not on hormonal contraception ( n = 117) sex hormones (dehydroepiandrosterone, androstenedione, testosterone, estrone, estadiol, sex hormone-binding globulin, prolactin). Testosterone ( n = 330) and sex hormone-binding globulin ( n = 318) were also measured at age 15.5 years. Regression models were used to estimate the relative difference (RD) in percent-water associated with one SD increment in hormone levels.
Results: Estradiol at age 21.5 and sex hormone-binding globulin at age 21.5 were positively associated with body mass index (BMI)-adjusted percent-water [RD (95% confidence interval (CI)): 3% (0%-7%) and 3% (1%-5%), respectively]. There was a positive nonlinear association between androstenedione at age 21.5 and percent-water. Insulin-like growth factor-I and growth hormone at age 21.5 were also positively associated with BMI-adjusted percent-water [RD (95% CI): 2% (0%-4%) and 4% (1%-7%), respectively].
Conclusions: The findings suggest that endogenous hormones affect breast tissue composition in young nulliparous women.
Impact: The well-established associations of childhood growth and development with breast cancer risk may be partly mediated by the role of endogenous hormones on breast tissue composition.
(©2018 American Association for Cancer Research.)
Methods: A cross-sectional study of 415 young (age ∼21.5 years) nulliparous women from an English prebirth cohort underwent a MRI examination of their breasts to estimate percent-water (a proxy for mammographic percent density) and provided a blood sample to measure plasma levels of growth factors (insulin-like growth factor-I, insulin-like growth factor-II, insulin growth factor-binding protein-3, growth hormone) and, if not on hormonal contraception ( n = 117) sex hormones (dehydroepiandrosterone, androstenedione, testosterone, estrone, estadiol, sex hormone-binding globulin, prolactin). Testosterone ( n = 330) and sex hormone-binding globulin ( n = 318) were also measured at age 15.5 years. Regression models were used to estimate the relative difference (RD) in percent-water associated with one SD increment in hormone levels.
Results: Estradiol at age 21.5 and sex hormone-binding globulin at age 21.5 were positively associated with body mass index (BMI)-adjusted percent-water [RD (95% confidence interval (CI)): 3% (0%-7%) and 3% (1%-5%), respectively]. There was a positive nonlinear association between androstenedione at age 21.5 and percent-water. Insulin-like growth factor-I and growth hormone at age 21.5 were also positively associated with BMI-adjusted percent-water [RD (95% CI): 2% (0%-4%) and 4% (1%-7%), respectively].
Conclusions: The findings suggest that endogenous hormones affect breast tissue composition in young nulliparous women.
Impact: The well-established associations of childhood growth and development with breast cancer risk may be partly mediated by the role of endogenous hormones on breast tissue composition.
(©2018 American Association for Cancer Research.)