학술논문
A possible unexpected link: Could wheat elimination trigger food protein-induced enterocolitis syndrome in a celiac disease patient?
Document Type
Report
Author
Furio S; NESMOS Department, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.; Mennini M; NESMOS Department, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.; Piccirillo M; NESMOS Department, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.; Ferrari F; U.O. Pediatria Ospedale Sant'Eugenio, Roma, Italy.; Pacchiarotti C; NESMOS Department, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.; Ferretti A; NESMOS Department, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.; Fiocchi AG; Department of Allergology, Children's Hospital Ospedale Pediatrico Bambino Gesù-IRCCS, Rome, Italy.; Parisi P; NESMOS Department, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy.; Di Nardo G; NESMOS Department, Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy. Electronic address: gionvanni.dinardo@uniroma1.it.
Source
Publisher: Elsevier Science Country of Publication: United States NLM ID: 8802712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1244 (Electronic) Linking ISSN: 08999007 NLM ISO Abbreviation: Nutrition Subsets: MEDLINE
Subject
Language
English
Abstract
Cases of association between celiac disease and wheat allergy have been described in the literature. However, to date, no reported cases have linked celiac disease with wheat food protein-induced enterocolitis syndrome (FPIES). We report a case of this association. A child diagnosed with celiac disease at the age of 2 years, following a gluten-free diet, experienced uncontrollable vomiting, and subsequent hypotension within 2 h of accidental ingestion of wheat flour. As a result, the child required hospitalization for fluid therapy. A similar episode occurred when the child turned 5 y, again resulting from accidental gluten ingestion. This time, the symptoms included vomiting, hypotension, and a loss of consciousness, leading to hospitalization for rehydration treatment. After this second episode, on suspicion of FPIES, the patient was referred to the pediatric allergists, who confirmed the diagnosis. To our knowledge, this is the first case of an association between celiac disease and FPIES. It has been hypothesized that exclusion diets in food-allergic children may lead to an increase in specific immunoglobulin E levels for those foods and, consequently, the risk of anaphylaxis. However, FPIES is not an immunoglobulin E-mediated condition. Hence, further investigations are warranted to elucidate the underlying mechanisms linking these 2 disorders.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)