학술논문
BMP2 rs1005464 is associated with mandibular condyle size variation.
Document Type
Academic Journal
Author
Marañón-Vásquez GA; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rua. Prof. Rodolpho Paulo Rocco, 325 - Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-617, Brazil.; de Souza Araújo MT; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rua. Prof. Rodolpho Paulo Rocco, 325 - Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-617, Brazil.; de Oliveira Ruellas AC; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rua. Prof. Rodolpho Paulo Rocco, 325 - Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-617, Brazil.; Matsumoto MAN; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café, s/n., Ribeirão Preto, São Paulo, 14040-904, Brazil.; Figueiredo M; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café, s/n., Ribeirão Preto, São Paulo, 14040-904, Brazil.; Meyfarth SRS; Department of Specific Formation, School of Dentistry, Fluminense Federal University, Rua. Dr. Silvio Henrique Braune, 22 - Centro, Nova Friburgo, Rio de Janeiro, 28625-650, Brazil.; Antunes LAA; Department of Specific Formation, School of Dentistry, Fluminense Federal University, Rua. Dr. Silvio Henrique Braune, 22 - Centro, Nova Friburgo, Rio de Janeiro, 28625-650, Brazil.; Baratto-Filho F; Post-Graduation Program, Tuiuti University of Paraná, R. Padre Ladislau Kula, 395 - Santo Inácio, Curitiba, Brazil.; School of Dentistry, Univille - Univille - University of the Joinville Region, Rua Paulo Malschitzki, 10 - Zona Industrial Norte, Joinville, Santa Catarina, 89219-710, Brazil.; Scariot R; Department of Stomatology, School of Dentistry, Federal University of Paraná, Av. Prefeito Lothário Meissner, 632 - Jardim Botânico, Curitiba, PR, 80210-170, Brazil.; Flores-Mir C; Graduate Orthodontic Program, School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, 5-528 Edmonton Clinic Health Academy, 11405 87 Ave NW, Edmonton, AB, T6G 1C9, Canada.; Kirschneck C; Department of Orthodontics, Medical Faculty, University Hospital Bonn, Welschnonnenstr. 17, 53111, Bonn, Germany.; Santos Antunes L; Department of Specific Formation, School of Dentistry, Fluminense Federal University, Rua. Dr. Silvio Henrique Braune, 22 - Centro, Nova Friburgo, Rio de Janeiro, 28625-650, Brazil.; Küchler EC; Department of Orthodontics, Medical Faculty, University Hospital Bonn, Welschnonnenstr. 17, 53111, Bonn, Germany. erika.kuchler@ukbonn.de.
Source
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Subject
Language
English
Abstract
This study aimed to evaluate the association between single nucleotide polymorphisms (SNPs) in endochondral development-related genes and mandibular condyle shape, size, volume, and symmetry traits. Cone-beam Computed Tomographies and genomic DNA from 118 individuals were evaluated (age range: 15-66 years). Data from twelve 3D landmarks on mandibular condyles were submitted to morphometric analyses including Procrustes fit, principal component analysis, and estimation of centroid sizes and fluctuating asymmetry scores. Condylar volumes were additionally measured. Seven SNPs across BMP2, BMP4, RUNX2 and SMAD6 were genotyped. Linear models were fit to evaluate the effect of the SNPs on the mandibular condyles' quantitative traits. Only the association between BMP2 rs1005464 and centroid size remained significant after adjusting to account for the false discovery rate due to multiple testing. Individuals carrying at least one A allele for this SNP showed larger condylar size than common homozygotes GG (β = 0.043; 95% CI: 0.014-0.071; P value = 0.028). The model including BMP2 rs1005464, age and sex of the participants explained 17% of the variation in condylar size. Shape, volume, and symmetry were not associated with the evaluated SNPs. These results suggest that BMP2 rs1005464 might be associated with variation in the mandibular condyles size.
(© 2024. The Author(s).)
(© 2024. The Author(s).)