학술논문
A contemporary review of clade-specific virological differences in monkeypox viruses.
Document Type
Academic Journal
Author
Okwor T; Department of Planning, Research & Statistics, Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria.; Mbala PK; Département de Virologie, Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo; Département de Biologie Médicale, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo.; Evans DH; Department of Medical Microbiology & Immunology and Li Ka Shing Institute of Virology, The University of Alberta, Edmonton, Alberta, Canada.; Kindrachuk J; Department of Medical Microbiology & Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: Jason.Kindrachuk@umanitoba.ca.
Source
Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Monkeypox virus (MPXV) is an emerging zoonotic virus that has had on-going public health impacts in endemic regions of Central and West Africa for over a half-century. Historically, the MPXV clade endemic in regions of Central Africa is associated with higher morbidity and mortality as compared with the clade endemic in West Africa.
Objectives: Here, we review the virological characteristics of MPXV and discuss potential relationships between virulence factors and clade- (and subclade-) specific differences in virulence and transmission patterns.
Sources: Targeted search was conducted in PubMed using ((monkeypox virus) OR (Orthopoxvirus)) AND (zoonosis)) OR ((monkeypox) OR (human mpox).
Content: Forty-seven references were considered that included three publicly available data reports and/or press releases, one book chapter, and 44 published manuscripts.
Implications: Although zoonosis has been historically linked to emergence events in humans, epidemiological analyses of more recent outbreaks have identified increasing frequencies of human-to-human transmission. Furthermore, viral transmission during the 2022 global human mpox outbreak, caused by a recently identified MPXV subclade, has relied exclusively on human-to-human contact with no known zoonotic link.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Objectives: Here, we review the virological characteristics of MPXV and discuss potential relationships between virulence factors and clade- (and subclade-) specific differences in virulence and transmission patterns.
Sources: Targeted search was conducted in PubMed using ((monkeypox virus) OR (Orthopoxvirus)) AND (zoonosis)) OR ((monkeypox) OR (human mpox).
Content: Forty-seven references were considered that included three publicly available data reports and/or press releases, one book chapter, and 44 published manuscripts.
Implications: Although zoonosis has been historically linked to emergence events in humans, epidemiological analyses of more recent outbreaks have identified increasing frequencies of human-to-human transmission. Furthermore, viral transmission during the 2022 global human mpox outbreak, caused by a recently identified MPXV subclade, has relied exclusively on human-to-human contact with no known zoonotic link.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)