학술논문
Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias.
Document Type
Academic Journal
Author
Lai RY; Department of Neurology, Columbia University Medical Center, New York, New York, USA.; Initiative of Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, New York, USA.; Rummey C; Clinical Data Science, Basel, Switzerland.; Amlang CJ; Department of Neurology, Columbia University Medical Center, New York, New York, USA.; Initiative of Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, New York, USA.; Department of Neurology, SUNY Downstate Health Sciences University, Brooklyn, New York, New York, USA.; Lin CR; Alzheimer's Disease and Parkinson's Disease Centers, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.; Chen TX; Department of Neurology, Columbia University Medical Center, New York, New York, USA.; Initiative of Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, New York, USA.; Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Perlman S; Department of Neurology, University of California Los Angeles, Los Angeles, California, USA.; Wilmot G; Department of Neurology, Emory University, Atlanta, Georgia, USA.; Gomez CM; Department of Neurology, University of Chicago, Chicago, Illinois, USA.; Schmahmann JD; Ataxia Center, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Paulson H; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.; Ying SH; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.; Onyike CU; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.; Zesiewicz TA; Department of Neurology, University of South Florida, Tampa, Florida, USA.; Bushara KO; Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.; Geschwind MD; Department of Neurology, University of California San Francisco, San Francisco, California, USA.; Figueroa KP; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.; Pulst SM; Department of Neurology, University of Utah, Salt Lake City, Utah, USA.; Subramony SH; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.; Burns MR; Department of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.; Opal P; Department of Neurology, Northwestern University, Chicago, Illinois, USA.; Duquette A; Centre Hospitalier de l'Université de Montréal, University of Montreal, Montreal, Quebec, Canada.; Ashizawa T; Houston Methodist Research Institute, Houston, Texas, USA.; Hamedani AG; Departments of Neurology, Ophthalmology, and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Davis MY; Department of Neurology, University of Washington, Seattle, Washington, USA.; Neurology Division, VA Puget Sound Health Care System, Seattle, WA, United States.; Srinivasan SR; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.; Moore LR; National Ataxia Foundation, Minneapolis, Minnesota, USA.; Shakkottai VG; Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Rosenthal LS; Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.; Kuo SH; Department of Neurology, Columbia University Medical Center, New York, New York, USA.; Initiative of Columbia Ataxia and Tremor, Columbia University Irving Medical Center, New York, New York, USA.
Source
Publisher: Wiley Country of Publication: United States NLM ID: 101630279 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2330-1619 (Electronic) Linking ISSN: 23301619 NLM ISO Abbreviation: Mov Disord Clin Pract Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Fatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated.
Objectives: To study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life.
Methods: Fatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life.
Results: Fatigue was most prevalent in SCA3 (52.6%), followed by SCA1 (36.7%), SCA6 (35.7%), and SCA2 (35.6%). SCA cases with fatigue had more severe ataxia and worse depressive symptoms. In SCA3, those with fatigue had a longer disease duration and longer pathological CAG repeat numbers. In multi-variable models, depressive symptoms, but not ataxia severity, were associated with more severe fatigue. Fatigue, independent of ataxia and depression, contributed to worse quality of life in SCA3 and SCA6 at baseline, and fatigue continued affecting quality of life throughout the disease course in all types of SCA.
Conclusions: Fatigue is a common symptom in SCAs and is closely related to depression. Fatigue significantly impacts patients' quality of life. Therefore, screening for fatigue should be considered a part of standard clinical care for SCAs.
(© 2024 International Parkinson and Movement Disorder Society.)
Objectives: To study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life.
Methods: Fatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life.
Results: Fatigue was most prevalent in SCA3 (52.6%), followed by SCA1 (36.7%), SCA6 (35.7%), and SCA2 (35.6%). SCA cases with fatigue had more severe ataxia and worse depressive symptoms. In SCA3, those with fatigue had a longer disease duration and longer pathological CAG repeat numbers. In multi-variable models, depressive symptoms, but not ataxia severity, were associated with more severe fatigue. Fatigue, independent of ataxia and depression, contributed to worse quality of life in SCA3 and SCA6 at baseline, and fatigue continued affecting quality of life throughout the disease course in all types of SCA.
Conclusions: Fatigue is a common symptom in SCAs and is closely related to depression. Fatigue significantly impacts patients' quality of life. Therefore, screening for fatigue should be considered a part of standard clinical care for SCAs.
(© 2024 International Parkinson and Movement Disorder Society.)