학술논문

Incidence, management and outcomes in hepatic artery complications after paediatric liver transplantation: protocol of the retrospective, international, multicentre HEPATIC Registry.
Document Type
Academic Journal
Author
Li W; Department of Radiology, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands.; van der Doef HPJ; Division of Paediatric Gastroenterology and Hepatology, Department of Paediatrics, University Medical Centre Groningen, Groningen, The Netherlands.; Wildhaber BE; Swiss Pediatric Liver Centre, Division of Child and Adolescent Surgery, Geneva University Hospitals, Geneva, Switzerland.; Marra P; Department of Radiology, ASST Papa Giovanni XXIII, Bergamo, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.; Bravi M; Department of Paediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy.; Pinelli D; Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy.; Minetto J; Division of Liver Transplant, Hospital de Pediatría Prof Dr Juan P Garrahan, Buenos Aires, Argentina.; Dip M; Division of Liver Transplant, Hospital de Pediatría Prof Dr Juan P Garrahan, Buenos Aires, Argentina.; Sierre S; Division of Interventional Radiology, Hospital de Pediatría Prof Dr Juan P Garrahan, Buenos Aires, Argentina.; de Santibañes M; HPB and Liver transplant unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.; Ardiles V; HPB and Liver transplant unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.; Uno JW; HPB and Liver transplant unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.; Hardikar W; Department of Gastroenterology, The Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia.; Bates S; Department of Gastroenterology, The Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia.; Goh L; Department of Gastroenterology, The Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia.; Aldrian D; Department of Paediatrics I, Medical University of Innsbruck, Innsbruck, Austria.; Seisenbacher J; Department of Paediatrics I, Medical University of Innsbruck, Innsbruck, Austria.; Vogel GF; Department of Paediatrics I, Medical University of Innsbruck, Innsbruck, Austria.; Institute of Cell Biology, Medical University of Innsbruck, Innsbruck, Austria.; Neto JS; Hepatology and Liver Transplantation, Hospital Sírio-Libanês, Sao Paulo, Brazil.; Antunes da Fonseca E; Hepatology and Liver Transplantation, Hospital Sírio-Libanês, Sao Paulo, Brazil.; Magalhães Costa C; Hepatology and Liver Transplantation, Hospital Sírio-Libanês, Sao Paulo, Brazil.; Ferreira CT; Department of Paediatrics, Hospital Santo Antonio, Salvador, Brazil.; Nader LS; Department of Paediatrics, Hospital Santo Antonio, Porto Alegre, Brazil.; Farina MA; Department of Paediatrics, Hospital Santo Antonio, Porto Alegre, Brazil.; Dajani KZ; Department of Surgery, Division of Transplantation Surgery, University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada.; Parente A; Department of Surgery, Division of Transplantation Surgery, University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada.; Bigam DL; Department of Surgery, Division of Transplantation Surgery, University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada.; Liang TB; Department of Hepatobiliary and Pancreatic Surgery, Liver Transplant Center, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.; Bai X; Department of Hepatobiliary and Pancreatic Surgery, Liver Transplant Center, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.; Zhang W; Department of Hepatobiliary and Pancreatic Surgery, Liver Transplant Center, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.; Gonsorčíková L; Department of Pediatrics, First Faculty of Medicine, Thomayer University Hospital, Praha, Czech Republic.; Froněk J; Department of Transplant Surgery, Institute of Clinical and Experimental medicine, Praha, Czech Republic.; Bohuš Š; Department of Pediatrics, First Faculty of Medicine, Thomayer University Hospital, Praha, Czech Republic.; Franchi-Abella S; Department of Paediatric Radiology, Paris-Saclay University, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.; Gonzales E; Paediatric Hepatology and Paediatric Liver Transplantation Unit, Paris-Saclay University, AP-HP, Hopital Bicetre, Le Kremlin-Bicêtre, France.; Guérin F; Paediatric Surgery and Paediatric Liver Transplantation Unit, Paris-Saclay University, AP-HP, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.; Junge N; Division for Pediatric Gastroenterology and Hepatology, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.; Baumann U; Division for Pediatric Gastroenterology and Hepatology, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.; Richter N; Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.; Hartleif S; Paediatric Gastroenterology and Hepatology, University Hospitals Tubingen, Tubingen, Germany.; Sturm E; Paediatric Gastroenterology and Hepatology, University Hospitals Tubingen, Tubingen, Germany.; Rajakannu M; Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.; Palaniappan K; Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.; Rela M; Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.; Pawaria A; Department of Pediatric Hepatology & Gastroenterology, Amrita Institute of Medical Sciences & Research Centre, New Delhi, Delhi, India.; Rajakrishnan H; Department of Solid organ transplantation, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.; Surendran S; Department of Solid organ transplantation, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India.; Kumar M; Centre for Liver and Biliary Sciences, Max Super Speciality Hospital Saket, New Delhi, Delhi, India.; Agarwal S; Centre for Liver and Biliary Sciences, Max Super Speciality Hospital Saket, New Delhi, Delhi, India.; Gupta S; Centre for Liver and Biliary Sciences, Max Super Speciality Hospital Saket, New Delhi, Delhi, India.; Asthana S; Integrated Liver Care Department, Aster CMI Hospital, Bengaluru, Karnataka, India.; Bandewar V; Integrated Liver Care Department, Aster CMI Hospital, Bengaluru, Karnataka, India.; Raichurkar K; Integrated Liver Care Department, Aster CMI Hospital, Bengaluru, Karnataka, India.; Spada M; Division of Hepatobiliopancreatic Surgery, Liver and Kidney Transplantion, Ospedale Pediatrico Bambino Gesu, Roma, Italy.; Monti L; Gastrointestinal and Transplanted Liver Imaging Unit, Ospedale Pediatrico Bambino Gesù, Roma, Italy.; Alterio T; Hepatology and Liver Transplant Unit, Ospedale Pediatrico Bambino Gesu, Roma, Italy.; Yanagi Y; Organ Transplantation Center, National Center for Child Health and Development, Setagaya-ku, Japan.; Uchida H; Organ Transplantation Centre, National Center for Child Health and Development Hospital, Tokyo, Japan.; Komine R; Organ Transplantation Center, National Center for Child Health and Development, Setagaya-ku, Japan.; Evans H; Department of Paediatric Gastroenterology, Starship Children's Health, Auckland, New Zealand.; Carr-Boyd P; New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, Auckland, New Zealand.; Duncan D; Department of Interventional Radiology, Auckland City Hospital, Auckland, Auckland, New Zealand.; Stefanowicz M; Department of Pediatric Surgery and Organ Transplantation, Children's Memorial Health Institute, Warszawa, Poland.; Latka-Grot J; Department of Pediatric Surgery and Organ Transplantation, Children's Memorial Health Institute, Warszawa, Poland.; Kolesnik A; Department of Pediatric Surgery and Organ Transplantation, Children's Memorial Health Institute, Warszawa, Poland.; Broering DC; Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.; Raptis DA; Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.; Ann H Marquez K; Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.; Mali V; National University Hospital, Singapore.; Aw M; Department of Paediatrics, National University Hospital, Singapore.; Beretta M; Department of Peadiatrics, Wits Donald Gordon Medical Centre, Johannesburg, South Africa.; Van der Schyff F; Department of surgery, Wits Donald Gordon Medical Centre, Johannesburg, South Africa.; Quintero-Bernabeu J; Pediatric Hepatology and Liver Trasplant Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Mercadal-Hally M; Pediatric Hepatology and Liver Trasplant Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Larrarte K M; Pediatric Hepatology and Liver Trasplant Department, Vall d'Hebron University Hospital, Barcelona, Spain.; Andres AM; Pediatric Surgery Department, La Paz University Hospital, Madrid, Madrid, Spain.; Hernandez-Oliveros F; Pediatric Surgery Department, La Paz University Hospital, Madrid, Madrid, Spain.; Frauca E; Pediatric Hepatology Department, La Paz University Hospital, Madrid, Madrid, Spain.; Casswall T; Department Clinical Interventions and Technology CLINTEC, Division for Paediatrics, Karolinska Institute, Stockholm, Sweden.; Jorns C; Division for Transplantation Surgery, Department Clinical Interventions and Technology CLINTEC, Karolinska Institute, Stockholm, Sweden.; Delle M; Department Clinical Science, Intervention and Technology CLINTEC, Division for Interventional Radiology, Karolinska Institute, Stockholm, Sweden.; Gupte G; Liver Unit (including small bowel transplantation), Birmingham Women's and Children's Hospitals NHS Foundation Trust, Birmingham, UK.; Sharif K; Liver Unit (including small bowel transplantation), Birmingham Women's and Children's Hospitals NHS Foundation Trust, Birmingham, UK.; McGuirk S; Department of Radiology, Birmingham Women's and Children's Hospitals NHS Foundation Trust, Birmingham, UK.; Superina R; Division of Transplant and Advanced Hepatobiliary Surgery, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.; Caicedo JC; Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Jaramillo C; Department of Paediatrics, Division of Paediatric Gastroenterology, Hepatology and Nutrition, University of Utah, Primary Children's Hospital, Salt Lake City, Utah, USA.; Bitterfeld L; Intermountain Primary Children's Hospital, Salt Lake City, Utah, USA.; Kastenberg Z; Department of Surgery, Division of Paediatric Surgery, University of Utah, Primary Children's Hospital, Salt Lake City, Utah, USA.; Shah AA; Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Domenick B; Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Acord MR; Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Mazariegos GV; Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.; Soltys K; Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.; DiNorcia J; Recanati-Miller Transplantation Institute, Mount Sinai Hospital, Los Angeles, California, USA.; Antala S; Recanati-Miller Transplantation Institute, Mount Sinai Hospital, Los Angeles, California, USA.; Florman SS; Recanati-Miller Transplantation Institute, Mount Sinai Hospital, Los Angeles, California, USA.; Buchholz BM; Department of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Herden U; Department of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Fischer L; Department of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Dierckx RAJO; Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands.; Hartog H; Department of Surgery, Section of Hepatobiliary Surgery & Liver Transplantation, University Medical Centre Groningen, Groningen, The Netherlands.; Bokkers RPH; Department of Radiology, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands r.p.h.bokkers@umcg.nl.
Source
Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: Hepatic artery complications (HACs), such as a thrombosis or stenosis, are serious causes of morbidity and mortality after paediatric liver transplantation (LT). This study will investigate the incidence, current management practices and outcomes in paediatric patients with HAC after LT, including early and late complications.
Methods and Analysis: The HEPatic Artery stenosis and Thrombosis after liver transplantation In Children (HEPATIC) Registry is an international, retrospective, multicentre, observational study. Any paediatric patient diagnosed with HAC and treated for HAC (at age <18 years) after paediatric LT within a 20-year time period will be included. The primary outcomes are graft and patient survivals. The secondary outcomes are technical success of the intervention, primary and secondary patency after HAC intervention, intraprocedural and postprocedural complications, description of current management practices, and incidence of HAC.
Ethics and Dissemination: All participating sites will obtain local ethical approval and (waiver of) informed consent following the regulations on the conduct of observational clinical studies. The results will be disseminated through scientific presentations at conferences and through publication in peer-reviewed journals.
Trial Registration Number: The HEPATIC registry is registered at the ClinicalTrials.gov website; Registry Identifier: NCT05818644.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)