학술논문

Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes.
Document Type
Academic Journal
Author
Kwak SH; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Hernandez-Cancela RB; Department of Biostatistics, Boston University School of Public Health, Boston, MA.; DiCorpo DA; Department of Biostatistics, Boston University School of Public Health, Boston, MA.; Condon DE; Sanford Imagenetics, Sanford Health, Sioux Falls, SD.; Merino J; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.; Wu P; Department of Biostatistics, Boston University School of Public Health, Boston, MA.; Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Yao J; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA.; Guo X; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA.; Ahmadizar F; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Department of Data Science and Biostatistics, Julius Global Health, University Medical Center Utrecht, Utrecht, the Netherlands.; Meyer M; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.; Sincan M; Department of Biostatistics, Boston University School of Public Health, Boston, MA.; Mercader JM; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Lee S; Division of Vascular Surgery and Endovascular Therapy, Massachusetts General Hospital, Boston, MA.; Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA.; Vy HMT; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; Lin Z; Department of Biostatistics, University of Minnesota, Minneapolis, MN.; Armstrong ND; Department of Epidemiology, The University of Alabama at Birmingham, Birmingham, AL.; Gu S; Department of Internal Medicine, Sanford Health, Sioux Falls, SD.; Tsao NL; Corporal Michael J. Crescenz VA Medical Center and Department of Surgery, Perelman School of Medicine, Philadelphia, PA.; Lange LA; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.; Wang N; Department of Biostatistics, Boston University School of Public Health, Boston, MA.; Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Trompet S; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Liu S; Department of Epidemiology, Brown University, Providence, RI.; Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; Judy R; Corporal Michael J. Crescenz VA Medical Center and Department of Surgery, Perelman School of Medicine, Philadelphia, PA.; Schroeder PH; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Hasbani NR; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX.; Bos MM; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX.; Jackson RD; Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Ohio State University, Columbus, OH.; Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; Manson JE; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Chaudhary NS; Department of Epidemiology, The University of Alabama at Birmingham, Birmingham, AL.; Carmichael LK; Department of Internal Medicine, Sanford Health, Sioux Falls, SD.; Chen YI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA.; Taylor KD; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA.; Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; van Meurs J; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Pitsillides AN; Department of Biostatistics, Boston University School of Public Health, Boston, MA.; Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA.; Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Do R; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; Park KS; Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.; Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands.; Kavousi M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.; Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS.; Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA.; Damrauer SM; Corporal Michael J. Crescenz VA Medical Center and Department of Surgery, Perelman School of Medicine, Philadelphia, PA.; Department of Genetics, Perelman School of Medicine, Philadelphia, PA.; Hajek C; Department of Internal Medicine, Sanford Health, Sioux Falls, SD.; Cho NH; Department of Preventive Medicine, Ajou University School of Medicine, Suwon, Korea.; Irvin MR; Department of Epidemiology, The University of Alabama at Birmingham, Birmingham, AL.; Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.; Nadkarni GN; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.; Sladek R; Department of Medicine and Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Goodarzi MO; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.; Florez JC; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Chasman DI; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Heckbert SR; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA.; Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.; Malhotra R; Cardiovascular Research Center, Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.; de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX.; Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA.; Rotter JI; Department of Pediatrics, Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA.; Meigs JB; Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA.; Department of Medicine, Harvard Medical School, Boston, MA.; Department of General Internal Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA.
Source
Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D).
Research Design and Methods: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD.
Results: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18.2%). We identified three novel genetic loci for incident CVD: rs147138607 (near CACNA1E/ZNF648, hazard ratio [HR] 1.23, P = 3.6 × 10-9), rs77142250 (near HS3ST1, HR 1.89, P = 9.9 × 10-9), and rs335407 (near TFB1M/NOX3, HR 1.25, P = 1.5 × 10-8). Among 204 known CAD loci, 5 were associated with incident CVD in T2D (multiple comparison-adjusted P < 0.00024, 0.05/204). A standardized polygenic score of these 204 variants was associated with incident CVD with HR 1.14 (P = 1.0 × 10-16).
Conclusions: The data point to novel and known genomic regions associated with incident CVD among individuals with T2D.
(© 2024 by the American Diabetes Association.)