학술논문
Cerebral collaterals are associated with pre-treatment brain-blood barrier permeability in acute ischemic stroke patients.
Document Type
Academic Journal
Author
Bani-Sadr A; Department of Neuroradiology, East Group Hospital, Hospices Civils de Lyon, Bron, France. apbanisadr@gmail.com.; CREATIS Laboratory, CNRS UMR 5220, INSERM U1294, Claude Bernard Lyon I University, Villeurbanne, France. apbanisadr@gmail.com.; Mechtouff L; Stroke Department, East Group Hospital, Hospices Civils de Lyon, Bron, France.; CarMeN Laboratory, INSERM U1060/INRA U1397, Claude Bernard Lyon I University, Bron, France.; Hermier M; Department of Neuroradiology, East Group Hospital, Hospices Civils de Lyon, Bron, France.; Eker OF; Department of Neuroradiology, East Group Hospital, Hospices Civils de Lyon, Bron, France.; CREATIS Laboratory, CNRS UMR 5220, INSERM U1294, Claude Bernard Lyon I University, Villeurbanne, France.; Rascle L; Stroke Department, East Group Hospital, Hospices Civils de Lyon, Bron, France.; de Bourguignon C; Clinical Investigation Center, INSERM 1407, Bron, France.; Boutelier T; Olea Medical, La Ciotat, France.; Martin A; Department of Neuroradiology, East Group Hospital, Hospices Civils de Lyon, Bron, France.; Tommasino E; Department of Neuroradiology, East Group Hospital, Hospices Civils de Lyon, Bron, France.; Ong E; Stroke Department, East Group Hospital, Hospices Civils de Lyon, Bron, France.; Fontaine J; Stroke Department, East Group Hospital, Hospices Civils de Lyon, Bron, France.; Cho TH; Stroke Department, East Group Hospital, Hospices Civils de Lyon, Bron, France.; CarMeN Laboratory, INSERM U1060/INRA U1397, Claude Bernard Lyon I University, Bron, France.; Derex L; Stroke Department, East Group Hospital, Hospices Civils de Lyon, Bron, France.; Nighoghossian N; Stroke Department, East Group Hospital, Hospices Civils de Lyon, Bron, France.; CarMeN Laboratory, INSERM U1060/INRA U1397, Claude Bernard Lyon I University, Bron, France.; Berthezene Y; Department of Neuroradiology, East Group Hospital, Hospices Civils de Lyon, Bron, France.; CREATIS Laboratory, CNRS UMR 5220, INSERM U1294, Claude Bernard Lyon I University, Villeurbanne, France.
Source
Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: To investigate the relationship between collaterals and blood-brain barrier (BBB) permeability on pre-treatment MRI in a cohort of acute ischemic stroke (AIS) patients treated with thrombectomy.
Methods: We conducted a retrospective analysis of the HIBISCUS-STROKE cohort, a single-center observational study that enrolled patients treated with thrombectomy from 2016 to 2022. Dynamic-susceptibility MRIs were post-processed to generate K2 maps with arrival-time correction, which were co-registered with apparent diffusion coefficient (ADC) maps. The 90th percentile of K2 was extracted from the infarct core-defined by an ADC ≤ 620 × 10-6 mm 2 /s with manual adjustments-and expressed as a percentage change compared to the contralateral white matter. Collaterals were assessed using pre-thrombectomy digital subtraction arteriography with an ASITN/SIR score < 3 defining poor collaterals.
Results: Out of 249 enrolled, 101 (40.6%) were included (median age: 72.0 years, 52.5% of males, median NIHSS score at admission: 15.0). Patients with poor collaterals (n = 44) had worse NIHSS scores (median: 16.0 vs 13.0, p = 0.04), larger infarct core volumes (median: 43.7 mL vs 9.5 mL, p < 0.0001), and higher increases in K2 (median: 346.3% vs 152.7%, p = 0.003). They were less likely to achieve successful recanalization (21/44 vs 51/57, p < 0.0001) and experienced more frequent hemorrhagic transformation (16/44 vs 9/57, p = 0.03). On multiple variable analysis, poor collaterals were associated with larger infarct cores (odds ratio (OR) = 1.12, 95% confidence interval (CI): [1.07, 1.17], p < 0.0001) and higher increases in K2 (OR = 6.63, 95% CI: [2.19, 20.08], p = 0.001).
Conclusion: Poor collaterals are associated with larger infarct cores and increased BBB permeability at admission MRI.
Clinical Relevance Statement: Poor collaterals are associated with a larger infarct core and increased BBB permeability at admission MRI of AIS patients treated with thrombectomy. These findings may have translational interests for extending thrombolytic treatment eligibility and developing neuroprotective strategies.
Key Points: In AIS, collaterals and BBB disruption have been both linked to hemorrhagic transformation. Poor collaterals were associated with larger ischemic cores and increased BBB permeability on pre-treatment MRI. These findings could contribute to hemorrhagic transformation risk stratification, thereby refining clinical decision-making for reperfusion therapies.
(© 2024. The Author(s), under exclusive licence to European Society of Radiology.)
Methods: We conducted a retrospective analysis of the HIBISCUS-STROKE cohort, a single-center observational study that enrolled patients treated with thrombectomy from 2016 to 2022. Dynamic-susceptibility MRIs were post-processed to generate K2 maps with arrival-time correction, which were co-registered with apparent diffusion coefficient (ADC) maps. The 90th percentile of K2 was extracted from the infarct core-defined by an ADC ≤ 620 × 10
Results: Out of 249 enrolled, 101 (40.6%) were included (median age: 72.0 years, 52.5% of males, median NIHSS score at admission: 15.0). Patients with poor collaterals (n = 44) had worse NIHSS scores (median: 16.0 vs 13.0, p = 0.04), larger infarct core volumes (median: 43.7 mL vs 9.5 mL, p < 0.0001), and higher increases in K2 (median: 346.3% vs 152.7%, p = 0.003). They were less likely to achieve successful recanalization (21/44 vs 51/57, p < 0.0001) and experienced more frequent hemorrhagic transformation (16/44 vs 9/57, p = 0.03). On multiple variable analysis, poor collaterals were associated with larger infarct cores (odds ratio (OR) = 1.12, 95% confidence interval (CI): [1.07, 1.17], p < 0.0001) and higher increases in K2 (OR = 6.63, 95% CI: [2.19, 20.08], p = 0.001).
Conclusion: Poor collaterals are associated with larger infarct cores and increased BBB permeability at admission MRI.
Clinical Relevance Statement: Poor collaterals are associated with a larger infarct core and increased BBB permeability at admission MRI of AIS patients treated with thrombectomy. These findings may have translational interests for extending thrombolytic treatment eligibility and developing neuroprotective strategies.
Key Points: In AIS, collaterals and BBB disruption have been both linked to hemorrhagic transformation. Poor collaterals were associated with larger ischemic cores and increased BBB permeability on pre-treatment MRI. These findings could contribute to hemorrhagic transformation risk stratification, thereby refining clinical decision-making for reperfusion therapies.
(© 2024. The Author(s), under exclusive licence to European Society of Radiology.)