학술논문
Association between psoas major muscle mass and CPET performance and long-term survival following major colorectal surgery: A retrospective cohort study.
Document Type
Academic Journal
Author
Hajibandeh S; Department of General Surgery, University Hospital of Wales, Cardiff, UK. Electronic address: Shahab_hajibandeh@yahoo.com.; Gilham I; Department of Radiology, University Hospital of Wales, Cardiff, UK.; Tam W; Department of Radiology, University Hospital of Wales, Cardiff, UK.; Kirby E; Department of Radiology, University Hospital of Wales, Cardiff, UK.; Babs-Osibodu AO; Department of Radiology, University Hospital of Wales, Cardiff, UK.; Jones W; Department of Radiology, University Hospital of Wales, Cardiff, UK.; Rose GA; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.; Bailey DM; Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.; Morris C; Department of General Surgery, University Hospital of Wales, Cardiff, UK.; Hargest R; Department of General Surgery, University Hospital of Wales, Cardiff, UK.; Clayton A; Department of Radiology, University Hospital of Wales, Cardiff, UK.; Davies RG; Department of Anaesthetics, University Hospital of Wales, Cardiff, UK.
Source
Publisher: Publications Office, The Royal College of Surgeons of Edinburgh Country of Publication: Scotland NLM ID: 101168329 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1479-666X (Print) Linking ISSN: 1479666X NLM ISO Abbreviation: Surgeon Subsets: MEDLINE
Subject
Language
English
ISSN
1479-666X
Abstract
Objectives: To evaluate whether computed tomography (CT)-derived psoas major muscle measurements could predict preoperative cardiopulmonary exercise testing (CPET) performance and long-term mortality in patients undergoing major colorectal surgery and to compare predictive performance of psoas muscle measurements using 2D approach and 3D approach.
Methods: A retrospective cohort study compliant with STROCSS standards was conducted. Consecutive patients undergoing major colorectal surgery between January 2011 and January 2017 following CPET as part of their preoperative assessment were included. Regression analyses were modelled to investigate association between the CT-derived psoas major muscle mass variables [total psoas muscle area (TPMA), total psoas muscle volume (TPMV) and psoas muscle index (PMI)] and CPET performance and mortality (1-year and 5-year). Discriminative performances of the variables were evaluated using Receiver Operating Characteristic (ROC) curve analysis.
Results: A total of 457 eligible patients were included. The median TPMA and TPMV were 21 cm2 (IQR: 15-27) and 274 cm 3 (IQR: 201-362), respectively. The median PMI measured via 2D and 3D approaches were 7 cm 2 /m 2 (IQR: 6-9) and 99 cm 3 /m 2 (IQR: 76-120), respectively. The risks of 1-year and 5-year mortality were 7.4% and 27.1%, respectively. Regression analyses showed TPMA, TPMV, and PMI can predict preoperative CPET performance and long-term mortality. However, ROC curve analyses showed no significant difference in predictive performance amongst TPMA, TPMV, and PMI.
Conclusion: Radiologically-measured psoas muscle mass variables may predict preoperative CPET performance and may be helpful with informing more objective selection of patients for preoperative CPET and prehabilitation.
Competing Interests: Declaration of competing interest Damian M. Bailey is Editor-in-Chief of Experimental Physiology, Chair of the Life Sciences Working Group, a member of the Human Spaceflight and Exploration Science Advisory Committee to the European Space Agency, a member of the Space Exploration Advisory Committee to the UK Space Agency, and a member of the National Cardiovascular Network for Wales and South East Wales Vascular Network. Damian M. Bailey is also affiliated to the companies FloTBI Inc. and Bexorg Inc., focused on the technological development of novel biomarkers of brain injury in humans. All other authors declare no conflict of interest.
(Copyright © 2024 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.)
Methods: A retrospective cohort study compliant with STROCSS standards was conducted. Consecutive patients undergoing major colorectal surgery between January 2011 and January 2017 following CPET as part of their preoperative assessment were included. Regression analyses were modelled to investigate association between the CT-derived psoas major muscle mass variables [total psoas muscle area (TPMA), total psoas muscle volume (TPMV) and psoas muscle index (PMI)] and CPET performance and mortality (1-year and 5-year). Discriminative performances of the variables were evaluated using Receiver Operating Characteristic (ROC) curve analysis.
Results: A total of 457 eligible patients were included. The median TPMA and TPMV were 21 cm
Conclusion: Radiologically-measured psoas muscle mass variables may predict preoperative CPET performance and may be helpful with informing more objective selection of patients for preoperative CPET and prehabilitation.
Competing Interests: Declaration of competing interest Damian M. Bailey is Editor-in-Chief of Experimental Physiology, Chair of the Life Sciences Working Group, a member of the Human Spaceflight and Exploration Science Advisory Committee to the European Space Agency, a member of the Space Exploration Advisory Committee to the UK Space Agency, and a member of the National Cardiovascular Network for Wales and South East Wales Vascular Network. Damian M. Bailey is also affiliated to the companies FloTBI Inc. and Bexorg Inc., focused on the technological development of novel biomarkers of brain injury in humans. All other authors declare no conflict of interest.
(Copyright © 2024 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.)