학술논문

Exposure to 4,4'-DDE in visceral adipose tissue and weight loss in adolescents from the Teen-LABS cohort.
Document Type
Academic Journal
Author
Rubbo B; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Li Z; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Tachachartvanich P; Department of Environmental Toxicology, University of California, Davis, California, USA.; Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Bangkok, Thailand.; Baumert BO; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Wang H; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Pan S; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Rock S; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Ryder JR; Department of Surgery, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.; Jenkins T; Division of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Sisley S; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.; Lin X; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Bartell S; Department of Environmental and Occupational Health and Department of Statistics, University of California, Irvine, California, USA.; Inge TH; Department of Surgery, Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.; Xanthakos S; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; McNeil B; Irving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA.; Robuck AR; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; La Merrill MA; Department of Environmental Toxicology, University of California, Davis, California, USA.; Walker DI; Gangarosa Department of Environmental Health, Emory University, Atlanta, Georgia, USA.; Conti DV; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; McConnell R; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Eckel SP; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Chatzi L; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Source
Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: Dichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integrative translational approach of epidemiological analysis among adolescents with obesity and in vitro measures exploring the impact of DDE on adipogenesis via preadipocytes.
Methods: We included 63 participants from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort. We assessed 4,4'-DDE in visceral adipose tissue at surgery and BMI and waist circumference at surgery and 0.5, 1, 3, and 5 years after. We conducted longitudinal analysis to estimate the interaction on weight loss between DDE and time since surgery. In vitro analysis quantified adipogenic differentiation in commercial human preadipocytes exposed to 4,4'-DDE via fluorescent staining and imaging.
Results: A dose-response relationship was observed, with the low-exposure group having a greater reduction in BMI during the first year compared to higher-exposure groups and showing smaller regains compared to higher-exposure groups after the first year. In vitro analysis of preadipocytes treated with 4,4'-DDE during adipogenic differentiation for 12 days showed a concentration-dependent increase in lipid accumulation.
Conclusions: DDE could contribute to weight trajectory among adolescents undergoing bariatric surgery, potentially mediated via promoted adipogenesis in preadipocytes.
(© 2024 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.)