학술논문
DNA damage in workers exposed to pigment grade titanium dioxide (TiO 2 ) and association with biomarkers of oxidative stress and inflammation.
Document Type
Academic Journal
Author
Bonetta S; Department of Public Health and Pediatrics, University of Torino, Via Santena 5 Bis, 10126 Torino, Italy. Electronic address: sara.bonetta@unito.it.; Macrì M; Department of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, Italy.; Acito M; Department of Pharmaceutical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.; Villarini M; Department of Pharmaceutical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.; Moretti M; Department of Pharmaceutical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy.; Bonetta S; Department of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123 Torino, Italy.; Bosio D; Department of Public Health and Pediatrics, University of Torino, Via Santena 5 Bis, 10126 Torino, Italy.; Mariella G; Department of Public Health and Pediatrics, University of Torino, Via Santena 5 Bis, 10126 Torino, Italy.; Bellisario V; Department of Public Health and Pediatrics, University of Torino, Via Santena 5 Bis, 10126 Torino, Italy.; Bergamaschi E; Department of Public Health and Pediatrics, University of Torino, Via Santena 5 Bis, 10126 Torino, Italy.; Carraro E; Department of Public Health and Pediatrics, University of Torino, Via Santena 5 Bis, 10126 Torino, Italy.
Source
Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9612020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7077 (Electronic) Linking ISSN: 13826689 NLM ISO Abbreviation: Environ Toxicol Pharmacol Subsets: MEDLINE
Subject
Language
English
Abstract
The present study was aimed at investigating DNA damage, micronuclei frequency and meta-nuclear alterations in buccal cells of workers involved in pigment-grade TiO 2 production (15 exposed and 20 not-exposed). We also assessed associations of genotoxicity biomarkers with oxidative stress/inflammatory biomarkers in urine and exhaled breath condensate (EBC), as well as possible associations between biomarkers and reported respiratory symptoms. In spite of compliance with TiO 2 Occupational Exposure Limits, results showed increased direct/oxidative DNA damage and micronuclei frequency in exposed workers. Genotoxicity parameters were associated with oxidative stress/inflammation biomarkers in urine and EBC, thus confirming that TiO 2 exposure can affect the oxidative balance. Workers with higher genotoxic/oxidative stress biomarkers levels reported early respiratory symptoms suggesting that molecular alterations can be predictive of early health dysfunctions. These findings suggest the need to assess early health impairment in health surveillance programs and to address properly safety issues in workplaces where TiO 2 is handled.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)