학술논문
A burden of proof study on alcohol consumption and ischemic heart disease.
Document Type
Academic Journal
Author
Carr S; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA. scarr@hsph.harvard.edu.; Bryazka D; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; McLaughlin SA; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Zheng P; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle, WA, USA.; Bahadursingh S; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK.; Aravkin AY; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle, WA, USA.; Department of Applied Mathematics, University of Washington, Seattle, WA, USA.; Hay SI; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle, WA, USA.; Lawlor HR; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Mullany EC; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Murray CJL; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle, WA, USA.; Nicholson SI; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Rehm J; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Faculty of Medicine, Institute of Medical Science (IMS), University of Toronto, Toronto, ON, Canada.; World Health Organization / Pan American Health Organization Collaborating Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Center for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.; Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.; Roth GA; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle, WA, USA.; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.; Sorensen RJD; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Lewington S; Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK.; Gakidou E; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.; Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle, WA, USA.
Source
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Subject
Language
English
Abstract
Cohort and case-control data have suggested an association between low to moderate alcohol consumption and decreased risk of ischemic heart disease (IHD), yet results from Mendelian randomization (MR) studies designed to reduce bias have shown either no or a harmful association. Here we conducted an updated systematic review and re-evaluated existing cohort, case-control, and MR data using the burden of proof meta-analytical framework. Cohort and case-control data show low to moderate alcohol consumption is associated with decreased IHD risk - specifically, intake is inversely related to IHD and myocardial infarction morbidity in both sexes and IHD mortality in males - while pooled MR data show no association, confirming that self-reported versus genetically predicted alcohol use data yield conflicting findings about the alcohol-IHD relationship. Our results highlight the need to advance MR methodologies and emulate randomized trials using large observational databases to obtain more definitive answers to this critical public health question.
(© 2024. The Author(s).)
(© 2024. The Author(s).)