학술논문
The histopathological diagnosis of atypical meningioma: glass slide versus whole slide imaging for grading assessment.
Document Type
Academic Journal
Author
Ammendola S; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.; Bariani E; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.; Eccher A; Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.; Capitanio A; Department of Clinical Pathology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.; Ghimenton C; Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.; Pantanowitz L; Department of Pathology & Clinical Labs, University of Michigan, Ann Arbor, MI, USA.; Parwani A; Department of Pathology, Wexner Medical Center, Ohio State University, Columbus, OH, USA.; Girolami I; Division of Pathology, Central Hospital Bolzano, Bolzano, Italy.; Scarpa A; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy.; ARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy.; Barresi V; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy. valeria.barresi@univr.it.; Department of Diagnostics and Public Health, Polyclinic G.B. Rossi, P.le L.A. Scuro, 10, 37134, Verona, Italy. valeria.barresi@univr.it.
Source
Publisher: Springer International Country of Publication: Germany NLM ID: 9423843 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2307 (Electronic) Linking ISSN: 09456317 NLM ISO Abbreviation: Virchows Arch Subsets: MEDLINE
Subject
Language
English
Abstract
Limited studies on whole slide imaging (WSI) in surgical neuropathology reported a perceived limitation in the recognition of mitoses. This study analyzed and compared the inter- and intra-observer concordance for atypical meningioma, using glass slides and WSI. Two neuropathologists and two residents assessed the histopathological features of 35 meningiomas-originally diagnosed as atypical-in a representative glass slide and corresponding WSI. For each histological parameter and final diagnosis, we calculated the inter- and intra-observer concordance in the two viewing modes and the predictive accuracy on recurrence. The concordance rates for atypical meningioma on glass slides and on WSI were 54% and 60% among four observers and 63% and 74% between two neuropathologists. The inter-observer agreement was higher using WSI than with glass slides for all parameters, with the exception of high mitotic index. For all histological features, we found median intra-observer concordance of ≥ 79% and similar predictive accuracy for recurrence between the two viewing modes. The higher concordance for atypical meningioma using WSI than with glass slides and the similar predictive accuracy for recurrence in the two modalities suggest that atypical meningioma may be safely diagnosed using WSI.