학술논문
Improved long-term patient-reported health and well-being outcomes of early-stage breast cancer treated with partial breast proton therapy.
Document Type
Academic Journal
Author
Teichman SL; Department of Radiation Medicine Loma, Linda University Medical Center, Loma Linda, California.; Do S; Department of Radiation Medicine Loma, Linda University Medical Center, Loma Linda, California.; Lum S; Department of Surgical Oncology, Loma Linda University Medical Center, Loma Linda, California.; Teichman TS; Department of Radiation Medicine Loma, Linda University Medical Center, Loma Linda, California.; Preston W; Department of Radiation Medicine Loma, Linda University Medical Center, Loma Linda, California.; Cochran SE; Department of Radiation Medicine Loma, Linda University Medical Center, Loma Linda, California.; Garberoglio CA; Department of Surgical Oncology, Loma Linda University Medical Center, Loma Linda, California.; Grove R; Department of Radiation Medicine Loma, Linda University Medical Center, Loma Linda, California.; Davis CA; Department of Radiation Medicine Loma, Linda University Medical Center, Loma Linda, California.; Slater JD; Department of Radiation Medicine Loma, Linda University Medical Center, Loma Linda, California.; Bush DA; Department of Radiation Medicine Loma, Linda University Medical Center, Loma Linda, California.
Source
Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Because early-stage breast cancer can be treated successfully by a variety of breast-conservation approaches, long-term quality of life (QoL) is an important consideration in assessing treatment outcomes for these patients. This study compares patient-reported QoL outcomes among women with stage 0-2 disease treated via lumpectomy followed by whole breast irradiation (WBI) or partial breast proton irradiation (PBPT).
Methods: In this cross-sectional study, 129 participants evaluated QoL several years post-treatment by responding to subjective instruments, including established scalar questionnaires and self-report measures. Responses were averaged between the two groups.
Results: At 6.5 years (median) postdiagnosis, participants' demographic, and clinical characteristics were similar. Patient-reported outcomes were reported as mean scale scores for the two groups, all displaying significant differences favoring PBPT, including: cosmetic breast cancer treatment outcome scale (BCTOS) (PBPT mean 1.45, WBI mean 1.88, P < 0.001); breast pain (PBPT mean 1.30, WBI mean 1.67, P < 0.05); breast texture (BPT mean 1.44, WBI mean 1.91, P < 0.001); clothing fit (PBPT mean 1.06, WBI 1.46, P < 0.001); fatigue (PBPT mean 2.24, WBI mean 3.77, P < 0.002); impact of daily life fatigue on personal relations (OBPT mean 0.83, WBI mean 2.15, P < 0.001); and self-consciousness (appearance dissatisfaction) (PBPT mean 1.38, WBI mean 1.77, P < 0.004).
Conclusion: Patients' responses suggest that PBPT is associated with improved overall QoL compared to standard whole breast treatment. These self-perceptions are reported by patients who are 5-10 years post-treatment, and that PBPT may enhance QoL in a multitude of interrelated ways.
(© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Methods: In this cross-sectional study, 129 participants evaluated QoL several years post-treatment by responding to subjective instruments, including established scalar questionnaires and self-report measures. Responses were averaged between the two groups.
Results: At 6.5 years (median) postdiagnosis, participants' demographic, and clinical characteristics were similar. Patient-reported outcomes were reported as mean scale scores for the two groups, all displaying significant differences favoring PBPT, including: cosmetic breast cancer treatment outcome scale (BCTOS) (PBPT mean 1.45, WBI mean 1.88, P < 0.001); breast pain (PBPT mean 1.30, WBI mean 1.67, P < 0.05); breast texture (BPT mean 1.44, WBI mean 1.91, P < 0.001); clothing fit (PBPT mean 1.06, WBI 1.46, P < 0.001); fatigue (PBPT mean 2.24, WBI mean 3.77, P < 0.002); impact of daily life fatigue on personal relations (OBPT mean 0.83, WBI mean 2.15, P < 0.001); and self-consciousness (appearance dissatisfaction) (PBPT mean 1.38, WBI mean 1.77, P < 0.004).
Conclusion: Patients' responses suggest that PBPT is associated with improved overall QoL compared to standard whole breast treatment. These self-perceptions are reported by patients who are 5-10 years post-treatment, and that PBPT may enhance QoL in a multitude of interrelated ways.
(© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)