학술논문
The effect of photobiomodulation on hearing loss: A systematic review.
Document Type
Academic Journal
Author
Nikookam Y; University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK.; Zia N; University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK.; Lotfallah A; University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK.; Muzaffar J; University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK.; University of Cambridge, Department of Clinical Neurosciences, Addenbrooke's Health Campus, Cambridge, UK.; Davis-Manders J; University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK.; Kullar P; University of Cambridge, Department of Clinical Neurosciences, Addenbrooke's Health Campus, Cambridge, UK.; Smith M; University of Cambridge, Department of Clinical Neurosciences, Addenbrooke's Health Campus, Cambridge, UK.; Bale G; Department of Physics, Cavendish Laboratory, Cambridge, UK.; Electrical Engineering, Cambridge, UK.; Boyle P; Advanced Bionics, Cambridge, UK.; Irving R; University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK.; Jiang D; Guy's and St Thomas' NHS Foundation Trust, Hearing Implant Centre, St. Thomas' Hospital, London, UK.; King's College London, Centre for Craniofacial and Regenerative Biology, London, UK.; Bance M; University of Cambridge, Department of Clinical Neurosciences, Addenbrooke's Health Campus, Cambridge, UK.
Source
Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 101247023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1749-4486 (Electronic) Linking ISSN: 17494478 NLM ISO Abbreviation: Clin Otolaryngol Subsets: MEDLINE
Subject
Language
English
Abstract
Objectives: To assess outcomes associated with photobiomodulation therapy (PBMT) for hearing loss in human and animal studies.
Design: Systematic review and narrative synthesis in accordance with PRISMA guidelines.
Setting: Data bases searched: MEDLINE, EMBASE, CENTRAL, ClinicalTrials.gov and Web of Science. No limits were placed on language or year of publication. Review conducted in accordance with the PRISMA 2020 statement.
Participants: All human and animal subjects treated with PBMT for hearing loss.
Main Outcome Measures: Pre- and post-PBMT audio metric outcomes.
Results: Searches identified 122 abstracts and 49 full text articles. Of these, 17 studies met the inclusion criteria, reporting outcomes in 327 animals (11 studies), 30 humans (1 study), and 40 animal specimens (5 studies). PBMT parameters included 6 different wavelengths: 908 nm (1 study), 810 nm (1 study), 532 & 635 nm (1 study), 830 nm (3 studies), 808 nm (11 studies). The duration ranged from 4 to 60 minutes in a session, and the follow-up ranged from 5-28 days. Outcomes improved significantly when wavelengths within the range of 800-830 nm were used, and with greater duration of PBMT exposure. Included studies predominantly consisted of non-randomized controlled trials (10 studies).
Conclusions: Hearing outcomes following PBMT appear to be superior to no PBMT for subjects with hearing loss, although higher level evidence is required to verify this. PBMT enables concentrated, focused delivery of light therapy to the inner ear through a non-invasive manner with minimal side effects. As a result of heterogeneity in reporting PBMT parameters and outcomes across the included studies, direct comparison is challenging.
(© 2023 The Authors. Clinical Otolaryngology published by John Wiley & Sons Ltd.)
Design: Systematic review and narrative synthesis in accordance with PRISMA guidelines.
Setting: Data bases searched: MEDLINE, EMBASE, CENTRAL, ClinicalTrials.gov and Web of Science. No limits were placed on language or year of publication. Review conducted in accordance with the PRISMA 2020 statement.
Participants: All human and animal subjects treated with PBMT for hearing loss.
Main Outcome Measures: Pre- and post-PBMT audio metric outcomes.
Results: Searches identified 122 abstracts and 49 full text articles. Of these, 17 studies met the inclusion criteria, reporting outcomes in 327 animals (11 studies), 30 humans (1 study), and 40 animal specimens (5 studies). PBMT parameters included 6 different wavelengths: 908 nm (1 study), 810 nm (1 study), 532 & 635 nm (1 study), 830 nm (3 studies), 808 nm (11 studies). The duration ranged from 4 to 60 minutes in a session, and the follow-up ranged from 5-28 days. Outcomes improved significantly when wavelengths within the range of 800-830 nm were used, and with greater duration of PBMT exposure. Included studies predominantly consisted of non-randomized controlled trials (10 studies).
Conclusions: Hearing outcomes following PBMT appear to be superior to no PBMT for subjects with hearing loss, although higher level evidence is required to verify this. PBMT enables concentrated, focused delivery of light therapy to the inner ear through a non-invasive manner with minimal side effects. As a result of heterogeneity in reporting PBMT parameters and outcomes across the included studies, direct comparison is challenging.
(© 2023 The Authors. Clinical Otolaryngology published by John Wiley & Sons Ltd.)