학술논문
Time-Lagged Functional Ultrasound for Multi-Parametric Cerebral Hemodynamic Imaging.
Document Type
Academic Journal
Author
Source
Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 8310780 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-254X (Electronic) Linking ISSN: 02780062 NLM ISO Abbreviation: IEEE Trans Med Imaging Subsets: MEDLINE
Subject
Language
English
Abstract
We introduce an ultrasound speckle decorrelation-based time-lagged functional ultrasound technique (tl-fUS) for the quantification of the relative changes in cerebral blood flow speed (rCBF [Formula: see text]), cerebral blood volume (rCBV) and cerebral blood flow (rCBF) during functional stimulations. Numerical simulations, phantom validations, and in vivo mouse brain experiments were performed to test the capability of tl-fUS to parse out and quantify the ratio change of these hemodynamic parameters. The blood volume change was found to be more prominent in arterioles compared to venules and the peak blood flow changes were around 2.5 times the peak blood volume change during brain activation, agreeing with previous observations in the literature. The tl-fUS shows the ability of distinguishing the relative changes of rCBFspeed, rCBV, and rCBF, which can inform specific physiological interpretations of the fUS measurements.