학술논문
Validation of an IGF1 Screening Method for Retinopathy of Pre-maturity.
Document Type
Academic Journal
Author
Pérez-Muñuzuri A; Neonatology Unit, University Clinical Hospital of Santiago, Santiago, Spain.; Department of Forensic Sciences, Pathology, Gynecology and Obstetrics, and Paediatrics, Health Research Institute of Santiago (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.; López-Suárez O; Neonatology Unit, University Clinical Hospital of Santiago, Santiago, Spain.; Department of Forensic Sciences, Pathology, Gynecology and Obstetrics, and Paediatrics, Health Research Institute of Santiago (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.; Mandiá-Rodríguez N; Neonatology Unit, University Clinical Hospital of Santiago, Santiago, Spain.; Department of Forensic Sciences, Pathology, Gynecology and Obstetrics, and Paediatrics, Health Research Institute of Santiago (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.; López-Sanguos C; Neonatology Unit, University Clinical Hospital of Santiago, Santiago, Spain.; Department of Forensic Sciences, Pathology, Gynecology and Obstetrics, and Paediatrics, Health Research Institute of Santiago (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.; Blanco-Teijeiro MJ; Retinal Unit, University Clinical Hospital of Santiago, Santiago, Spain.; Department of Ophthalmology, Health Research Institute of Santiago (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.; Couce ML; Neonatology Unit, University Clinical Hospital of Santiago, Santiago, Spain.; Department of Forensic Sciences, Pathology, Gynecology and Obstetrics, and Paediatrics, Health Research Institute of Santiago (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain.
Source
Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101615492 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2360 (Print) Linking ISSN: 22962360 NLM ISO Abbreviation: Front Pediatr Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2296-2360
Abstract
Retinopathy of pre-maturity (ROP) is a retinal disease that causes arrest of vascularization of the retina and can result in retinal detachment and blindness. Current screening protocols may not be sufficiently accurate to identify all at-risk patients. The aim of this study is to validate a method for improved identification of newborns at risk of ROP. We conducted a prospective clinical trial of pre-term newborns <32 weeks of gestation and/or <1,500 g birth weight during a 6-year period in a tertiary care hospital. We applied our new method based on measurement of insulin-like growth factor 1 (IGF1) levels at 3 weeks of age and the presence of sepsis during the first 3 weeks of life. Our screening protocol allowed exclusion of 121 (79.1%) patients for whom American Academy of Pediatrics (AAP) guidelines recommended screening, had a negative predictive value of 100%, and correctly identified all patients with ROP. Following retrospective assessment of our data based on these findings, we propose further restriction of the current AAP indications for screening to <1,100 g and <28 weeks of gestation in order to improve diagnostic efficacy while ensuring optimal use of restriction of human and material resources.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2020 Pérez-Muñuzuri, López-Suárez, Mandiá-Rodríguez, López-Sanguos, Blanco-Teijeiro and Couce.)
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2020 Pérez-Muñuzuri, López-Suárez, Mandiá-Rodríguez, López-Sanguos, Blanco-Teijeiro and Couce.)