학술논문
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
Document Type
Academic Journal
Author
Gudmundsson J; deCODE genetics, 101 Reykjavik, Iceland. julius@decode.is; Sulem P; Rafnar T; Bergthorsson JT; Manolescu A; Gudbjartsson D; Agnarsson BA; Sigurdsson A; Benediktsdottir KR; Blondal T; Jakobsdottir M; Stacey SN; Kostic J; Kristinsson KT; Birgisdottir B; Ghosh S; Magnusdottir DN; Thorlacius S; Thorleifsson G; Zheng SL; Sun J; Chang BL; Elmore JB; Breyer JP; McReynolds KM; Bradley KM; Yaspan BL; Wiklund F; Stattin P; Lindström S; Adami HO; McDonnell SK; Schaid DJ; Cunningham JM; Wang L; Cerhan JR; St Sauver JL; Isaacs SD; Wiley KE; Partin AW; Walsh PC; Polo S; Ruiz-Echarri M; Navarrete S; Fuertes F; Saez B; Godino J; Weijerman PC; Swinkels DW; Aben KK; Witjes JA; Suarez BK; Helfand BT; Frigge ML; Kristjansson K; Ober C; Jonsson E; Einarsson GV; Xu J; Gronberg H; Smith JR; Thibodeau SN; Isaacs WB; Catalona WJ; Mayordomo JI; Kiemeney LA; Barkardottir RB; Gulcher JR; Thorsteinsdottir U; Kong A; Stefansson K
Source
Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Subject
Language
English
Abstract
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.