학술논문
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
Document Type
Academic Journal
Author
Gudmundsson J; deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland. julius.gudmundsson@decode.is; Sulem P; Steinthorsdottir V; Bergthorsson JT; Thorleifsson G; Manolescu A; Rafnar T; Gudbjartsson D; Agnarsson BA; Baker A; Sigurdsson A; Benediktsdottir KR; Jakobsdottir M; Blondal T; Stacey SN; Helgason A; Gunnarsdottir S; Olafsdottir A; Kristinsson KT; Birgisdottir B; Ghosh S; Thorlacius S; Magnusdottir D; Stefansdottir G; Kristjansson K; Bagger Y; Wilensky RL; Reilly MP; Morris AD; Kimber CH; Adeyemo A; Chen Y; Zhou J; So WY; Tong PC; Ng MC; Hansen T; Andersen G; Borch-Johnsen K; Jorgensen T; Tres A; Fuertes F; Ruiz-Echarri M; Asin L; Saez B; van Boven E; Klaver S; Swinkels DW; Aben KK; Graif T; Cashy J; Suarez BK; van Vierssen Trip O; Frigge ML; Ober C; Hofker MH; Wijmenga C; Christiansen C; Rader DJ; Palmer CN; Rotimi C; Chan JC; Pedersen O; Sigurdsson G; Benediktsson R; Jonsson E; Einarsson GV; Mayordomo JI; Catalona WJ; Kiemeney LA; Barkardottir RB; Gulcher JR; Thorsteinsdottir U; Kong A; Stefansson K
Source
Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1061-4036 (Print) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Subject
Language
English
ISSN
1061-4036
Abstract
We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually (allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.