학술논문
Risk factors for prevalent and incident hypertension in rheumatoid arthritis: data from the Canadian Early Arthritis Cohort.
Document Type
Academic Journal
Author
Hadwen B; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.; Stranges S; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.; Department of Family Medicine, Western University, London, Ontario, Canada.; Lawson Health Research Institute, London, Ontario, Canada.; Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg.; Pope JE; Department of Medicine, Division of Rheumatology, Western University, London, Ontario, Canada.; Bartlett S; Department of Medicine, Division of Rheumatology, McGill University, Montreal, Quebec, Canada.; Boire G; Department of Medicine, Division of Rheumatology, Centre Intégré Universitaire de Santé et de Services Sociaux de l'Estrie-Centre Hospitalier Universitaire de Sherbrooke and Université de Sherbrooke, Sherbrooke, Quebec, Canada.; Bessette L; Department of Medicine, Division of Rheumatology, Université Laval, Quebec, Quebec, Canada.; Hitchon CA; Department of Internal Medicine, Section of Rheumatology, University of Manitoba, Winnipeg, Manitoba, Canada.; Hazlewood G; Department of Medicine, Division of Rheumatology, University of Calgary, Calgary, Alberta, Canada.; Keystone EC; Department of Medicine, Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada.; Schieir O; Department of Medicine, Division of Rheumatology, McGill University, Montreal, Quebec, Canada.; Thorne C; Centre of Arthritis Excellence, Newmarket, Ontario, Canada.; Tin D; Centre of Arthritis Excellence, Newmarket, Ontario, Canada.; Valois MF; Department of Medicine, Division of Rheumatology, McGill University, Montreal, Quebec, Canada.; Bykerk V; Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical, New York, NY, USA.; Barra L; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.; Lawson Health Research Institute, London, Ontario, Canada.; Department of Medicine, Division of Rheumatology, Western University, London, Ontario, Canada.
Source
Publisher: Oxford University Press Country of Publication: England NLM ID: 101736676 Publication Model: eCollection Cited Medium: Internet ISSN: 2514-1775 (Electronic) Linking ISSN: 25141775 NLM ISO Abbreviation: Rheumatol Adv Pract Subsets: PubMed not MEDLINE
Subject
Language
English
Abstract
Objective: Hypertension (HTN) is a common comorbidity in RA. This study aimed to explore the prevalence and incidence of HTN and baseline factors associated with incident HTN in early RA (ERA).
Methods: Data were from the Canadian Early Arthritis Cohort (CATCH), an inception cohort of ERA patients having <1 year of disease duration. HTN was determined by patient- or physician-reported diagnosis, the use of anti-hypertensives and/or blood pressure. Multivariable logistic regression was performed to determine baseline factors associated with prevalent and incident HTN in this population.
Results: The study sample included 2052 ERA patients [mean age 55 years (s.d. 14), 71% female). The prevalence of HTN at study enrolment was 26% (23% in females and 34% in males). In both sexes, prevalent HTN was associated with older age, diabetes and hyperlipidaemia. HTN was associated with being overweight or high alcohol consumption in females. Of the RA patients who did not have HTN at enrolment, 24% (364/1518) developed HTN during the median follow-up period of 5 years (range 1-8). Baseline factors significantly associated with incident HTN were older age, being overweight, excess alcohol consumption and having hyperlipidaemia. Incident HTN was associated with high alcohol consumption in males and with hyperlipidaemia in females. RA-associated disease factors and treatments were not significantly associated with prevalent or incident HTN.
Conclusions: Early RA patients had a high incidence of hypertension with the highest risk in older patients with traditional cardiovascular risk factors.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology.)
Methods: Data were from the Canadian Early Arthritis Cohort (CATCH), an inception cohort of ERA patients having <1 year of disease duration. HTN was determined by patient- or physician-reported diagnosis, the use of anti-hypertensives and/or blood pressure. Multivariable logistic regression was performed to determine baseline factors associated with prevalent and incident HTN in this population.
Results: The study sample included 2052 ERA patients [mean age 55 years (s.d. 14), 71% female). The prevalence of HTN at study enrolment was 26% (23% in females and 34% in males). In both sexes, prevalent HTN was associated with older age, diabetes and hyperlipidaemia. HTN was associated with being overweight or high alcohol consumption in females. Of the RA patients who did not have HTN at enrolment, 24% (364/1518) developed HTN during the median follow-up period of 5 years (range 1-8). Baseline factors significantly associated with incident HTN were older age, being overweight, excess alcohol consumption and having hyperlipidaemia. Incident HTN was associated with high alcohol consumption in males and with hyperlipidaemia in females. RA-associated disease factors and treatments were not significantly associated with prevalent or incident HTN.
Conclusions: Early RA patients had a high incidence of hypertension with the highest risk in older patients with traditional cardiovascular risk factors.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology.)