학술논문
The Pathogenesis of Bronchiectasis.
Document Type
Academic Journal
Author
Metersky ML; Division of Pulmonary, Critical Care and Sleep Medicine, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-1321, USA. Electronic address: Metersky@uchc.edu.; Barker AF; Division of Pulmonary and Critical Care Medicine, UHN-67, Oregon Health and Science University, Portland, OR 97239, USA.
Source
Publisher: Elsevier Health Sciences Division Country of Publication: United States NLM ID: 7907612 Publication Model: Print Cited Medium: Internet ISSN: 1557-8216 (Electronic) Linking ISSN: 02725231 NLM ISO Abbreviation: Clin Chest Med Subsets: MEDLINE
Subject
Language
English
Abstract
Bronchiectasis is a condition defined by permanently dilated airways and characterized by chronic cough and sputum and in many patients, recurrent exacerbations. Bronchiectasis is a heterogeneous condition, with numerous underlying risk factors and initiating conditions. These factors share in common the ability to impair the mechanisms by which the airways are protected from inflammatory or infectious insults. These underlying factors result in chronic bacterial infection of the airways, inciting a host inflammatory response in which the airways are the collateral damage. The damaged airways are unable to clear the infection, leading to ongoing inflammation and progressive damage.
Competing Interests: Disclosure Dr M.L. Metersky has served as a consultant for Insmed, Zambon and International Biophysics and has served as an Investigator in a clinical trial sponsored by Insmed. Dr A.F. Barker has no financial conflicts of interest to report.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Competing Interests: Disclosure Dr M.L. Metersky has served as a consultant for Insmed, Zambon and International Biophysics and has served as an Investigator in a clinical trial sponsored by Insmed. Dr A.F. Barker has no financial conflicts of interest to report.
(Copyright © 2021 Elsevier Inc. All rights reserved.)