학술논문
Risk Factors and Attack Rates of Seasonal Influenza Infection: Results of the Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance (SHIVERS) Seroepidemiologic Cohort Study.
Document Type
Academic Journal
Author
Huang QS; Institute of Environmental Science and Research, Wellington.; Bandaranayake D; Institute of Environmental Science and Research, Wellington.; Wood T; Institute of Environmental Science and Research, Wellington.; Newbern EC; Institute of Environmental Science and Research, Wellington.; Seeds R; Institute of Environmental Science and Research, Wellington.; Ralston J; Institute of Environmental Science and Research, Wellington.; Waite B; Institute of Environmental Science and Research, Wellington.; Bissielo A; Institute of Environmental Science and Research, Wellington.; Prasad N; Institute of Environmental Science and Research, Wellington.; Todd A; Institute of Environmental Science and Research, Wellington.; Jelley L; Institute of Environmental Science and Research, Wellington.; Gunn W; Institute of Environmental Science and Research, Wellington.; McNicholas A; Institute of Environmental Science and Research, Wellington.; Metz T; Institute of Environmental Science and Research, Wellington.; Lawrence S; Counties Manukau District Health Board, Auckland, New Zealand.; Collis E; Counties Manukau District Health Board, Auckland, New Zealand.; Retter A; Counties Manukau District Health Board, Auckland, New Zealand.; Wong SS; World Health Organization Collaborating Centre, St Jude Children's Research Hospital, Memphis, Tennessee.; Webby R; World Health Organization Collaborating Centre, St Jude Children's Research Hospital, Memphis, Tennessee.; Bocacao J; Institute of Environmental Science and Research, Wellington.; Haubrock J; Institute of Environmental Science and Research, Wellington.; Mackereth G; Institute of Environmental Science and Research, Wellington.; Turner N; University of Auckland.; McArdle B; University of Auckland.; Cameron J; Westmere Medical Centre, Auckland.; Reynolds EG; University of Auckland.; Baker MG; University of Otago School of Medicine, Wellington.; Grant CC; University of Auckland.; McArthur C; Auckland District Health Board, New Zealand.; Roberts S; Auckland District Health Board, New Zealand.; Trenholme A; Counties Manukau District Health Board, Auckland, New Zealand.; Wong C; Counties Manukau District Health Board, Auckland, New Zealand.; Taylor S; Counties Manukau District Health Board, Auckland, New Zealand.; Thomas P; World Health Organization Collaborating Centre, St Jude Children's Research Hospital, Memphis, Tennessee.; Duque J; Centers for Disease Control and Prevention, Atlanta, Georgia.; Gross D; Centers for Disease Control and Prevention, Atlanta, Georgia.; Thompson MG; Centers for Disease Control and Prevention, Atlanta, Georgia.; Widdowson MA; Centers for Disease Control and Prevention, Atlanta, Georgia.
Source
Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Understanding the attack rate of influenza infection and the proportion who become ill by risk group is key to implementing prevention measures. While population-based studies of antihemagglutinin antibody responses have been described previously, studies examining both antihemagglutinin and antineuraminidase antibodies are lacking.
Methods: In 2015, we conducted a seroepidemiologic cohort study of individuals randomly selected from a population in New Zealand. We tested paired sera for hemagglutination inhibition (HAI) or neuraminidase inhibition (NAI) titers for seroconversion. We followed participants weekly and performed influenza polymerase chain reaction (PCR) for those reporting influenza-like illness (ILI).
Results: Influenza infection (either HAI or NAI seroconversion) was found in 321 (35% [95% confidence interval, 32%-38%]) of 911 unvaccinated participants, of whom 100 (31%) seroconverted to NAI alone. Young children and Pacific peoples experienced the highest influenza infection attack rates, but overall only a quarter of all infected reported influenza PCR-confirmed ILI, and one-quarter of these sought medical attention. Seroconversion to NAI alone was higher among children aged <5 years vs those aged ≥5 years (14% vs 4%; P < .001) and among those with influenza B vs A(H3N2) virus infections (7% vs 0.3%; P < .001).
Conclusions: Measurement of antineuraminidase antibodies in addition to antihemagglutinin antibodies may be important in capturing the true influenza infection rates.
Methods: In 2015, we conducted a seroepidemiologic cohort study of individuals randomly selected from a population in New Zealand. We tested paired sera for hemagglutination inhibition (HAI) or neuraminidase inhibition (NAI) titers for seroconversion. We followed participants weekly and performed influenza polymerase chain reaction (PCR) for those reporting influenza-like illness (ILI).
Results: Influenza infection (either HAI or NAI seroconversion) was found in 321 (35% [95% confidence interval, 32%-38%]) of 911 unvaccinated participants, of whom 100 (31%) seroconverted to NAI alone. Young children and Pacific peoples experienced the highest influenza infection attack rates, but overall only a quarter of all infected reported influenza PCR-confirmed ILI, and one-quarter of these sought medical attention. Seroconversion to NAI alone was higher among children aged <5 years vs those aged ≥5 years (14% vs 4%; P < .001) and among those with influenza B vs A(H3N2) virus infections (7% vs 0.3%; P < .001).
Conclusions: Measurement of antineuraminidase antibodies in addition to antihemagglutinin antibodies may be important in capturing the true influenza infection rates.