학술논문
The relation between pro-oxidant antioxidant balance and glycolipid profile, 6 months after gastric bypass surgery.
Document Type
Academic Journal
Author
Banazadeh V; Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Nematy M; Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.; Ghayour Mobarhan M; Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.; Tavallaie S; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Esmaily H; Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Jangjoo A; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: JangjooA@mums.ac.ir.
Source
Publisher: Elsevier Country of Publication: United States NLM ID: 101233161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7533 (Electronic) Linking ISSN: 15507289 NLM ISO Abbreviation: Surg Obes Relat Dis Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Morbid obesity is a chronic disease that contributes to increased oxidative stress. Gastric bypass surgery is the gold standard method in treating co-morbidities.
Objectives: The objective of this study was to evaluate the relation between pro-oxidant antioxidant balance (PAB) as one measure of oxidative stress and glycolipid profile 6 months after gastric bypass surgery.
Setting: Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Methods: Thirty-five morbidly obese patients with body mass index ≥35 kg/m2 with co-morbidities or ≤40 kg/m 2 were randomly recruited. The PAB assay was used to estimate oxidative stress. Anthropometrics and glycolipid profile were collected at recruitment and 6 months after surgery. Statistical analysis was performed using SPSS 16 software.
Results: The study showed a significant postoperative reduction in serum PAB values compared with the baseline (P<.001). All anthropometric and several glycolipid parameters significantly reduced after surgery (P<.001), while serum high-density lipoprotein cholesterol was unaffected. Repeated measures analysis of variance showed that postoperative PAB values were affected by gastric bypass surgery (F = 12.51, P = .001). Regression analysis demonstrated medication usage controlling co-morbidities (β^ = -.6, P = .002) and fasting blood glucose (β^ = .41, P = .04) as independent factors in predicting PAB values 6 months after surgery.
Conclusions: Gastric bypass surgery can reduce PAB values in favor of antioxidants 6 months after the operation. Accordingly, fasting blood glucose after gastric bypass surgery can be an independent factor in predicting PAB values.
(Copyright © 2018 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.)
Objectives: The objective of this study was to evaluate the relation between pro-oxidant antioxidant balance (PAB) as one measure of oxidative stress and glycolipid profile 6 months after gastric bypass surgery.
Setting: Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Methods: Thirty-five morbidly obese patients with body mass index ≥35 kg/m
Results: The study showed a significant postoperative reduction in serum PAB values compared with the baseline (P<.001). All anthropometric and several glycolipid parameters significantly reduced after surgery (P<.001), while serum high-density lipoprotein cholesterol was unaffected. Repeated measures analysis of variance showed that postoperative PAB values were affected by gastric bypass surgery (F = 12.51, P = .001). Regression analysis demonstrated medication usage controlling co-morbidities (β^ = -.6, P = .002) and fasting blood glucose (β^ = .41, P = .04) as independent factors in predicting PAB values 6 months after surgery.
Conclusions: Gastric bypass surgery can reduce PAB values in favor of antioxidants 6 months after the operation. Accordingly, fasting blood glucose after gastric bypass surgery can be an independent factor in predicting PAB values.
(Copyright © 2018 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.)