학술논문
Epicatechin gallate improves healing and reduces scar formation of incisional wounds in type 2 diabetes mellitus rat model.
Document Type
Academic Journal
Author
McKelvey KJ; Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand; email: kelly.mckelvey@sydney.edu.au.; Appleton I; Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand.
Source
Publisher: HMP Global Country of Publication: United States NLM ID: 9010276 Publication Model: Print Cited Medium: Print ISSN: 1044-7946 (Print) Linking ISSN: 10447946 NLM ISO Abbreviation: Wounds Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
1044-7946
Abstract
Diabetic foot ulcers are the most severe clinical manifestation of diabetes-related impaired wound healing. Current standard and experimental treatments for these ulcers are largely ineffective. Epicatechin gallate (ECG) is a nontoxic flavonoid previously shown to improve normal wound healing and scar formation. In this study, the neonatal streptozotocin-induced diabetes mellitus (nSTZ-DM) type 2 model in rats was used to investigate the effects of ECG on impaired wound healing and scar formation. Administration of 100 mg/kg STZ induced a significant (P < 0.05) state of mild hyperglycemia in nSTZ-DM type 2 rats, compared to nondiabetic controls. The effects of 0.8 mg/mL ECG on wound healing were then investigated using the full-thickness incisional wound-healing model. ECG significantly improves healing and reduces scar formation in nSTZ-DM type 2 rats (P < 0.05). Biochemical improvements were also found, including significantly increased total nitric oxide synthase activity ([NOS]; P < 0.001) and inducible NOS (iNOS) activity (P < 0.01). This work highlights ECG as a potential treatment for DM-impaired wound healing. .