학술논문
Superoxide Dismutase-Mimetic Polyphenol-Based Carbon Dots for Multimodal Bioimaging and Treatment of Atopic Dermatitis.
Document Type
Academic Journal
Author
Han J; Department of Chemical Engineering (BK21 FOUR), Dong-A University, Busan 49315, Republic of Korea.; Choi S; Department of Chemical Engineering (BK21 FOUR), Dong-A University, Busan 49315, Republic of Korea.; Hong J; Department of Chemical Engineering (BK21 FOUR), Dong-A University, Busan 49315, Republic of Korea.; Gang D; Department of Chemical Engineering (BK21 FOUR), Dong-A University, Busan 49315, Republic of Korea.; Lee S; Department of Chemical Engineering (BK21 FOUR), Dong-A University, Busan 49315, Republic of Korea.; Department of Chemistry, Dong-A University, Busan 49315, Republic of Korea.; Shin K; Department of Polymer Science and Engineering and Program in Environmental and Polymer Engineering, Inha University, Incheon 22212, Republic of Korea.; Ko J; School of Chemical and Biological Engineering, The Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.; Kim JU; School of Chemical and Biological Engineering, The Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.; Hwang NS; School of Chemical and Biological Engineering, The Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.; Bio-MAX/N-Bio, Institute of Bioengineering, Institute of Engineering Research, Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.; An YH; School of Chemical and Biological Engineering, The Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.; Bio-MAX/N-Bio, Institute of Bioengineering, Institute of Engineering Research, Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea.; Gu M; Department of Chemical Engineering (BK21 FOUR), Dong-A University, Busan 49315, Republic of Korea.; Kim SH; Department of Chemical Engineering (BK21 FOUR), Dong-A University, Busan 49315, Republic of Korea.
Source
Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
Subject
Language
English
Abstract
Polyphenols have been investigated for their potential to mitigate inflammation in the context of atopic dermatitis (AD). In this study, epigallocatechin-3-gallate (EGCG)-based carbon dots (EGCG@CDs) were developed to enhance transdermal penetration, reduce inflammation, recapitulate superoxide dismutase (SOD) activity, and provide antimicrobial effects for AD treatment. The water-soluble EGCG@CDs in a few nanometers size exhibit a negative zeta potential, making them suitable for effective transdermal penetration. The fluorescence properties, including an upconversion effect, make EGCG@CDs suitable imaging probes for both in vitro and in vivo applications. By mimicking the SOD enzyme, EGCG@CDs scavenge reactive oxygen species (ROS) and actively produce hydrogen peroxide through a highly catalytic capability toward the oxygen reduction reaction, resulting in the inhibition of bacterial growth. The enhanced antioxidant properties, high charge mobility, and various functional groups of EGCG@CDs prove effective in reducing intracellular ROS in an in vitro AD model. In the mouse AD model, EGCG@CDs incorporated into a hydrogel actively penetrated the epidermal layer, leading to ROS scavenging, reduced mast cell activation, and histological recovery of skin barriers. This research represents the versatile potential of EGCG@CDs in addressing AD and advancing tissue engineering.