학술논문
Diabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium.
Document Type
Academic Journal
Author
Ho NT; Research Management Department, Vinmec Healthcare System, Hanoi, Vietnam.; Abe SK; Division of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Rahman MS; Division of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan.; Islam R; Division of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Hitotsubashi Institute for Advanced Study, Hitotsubashi University, Tokyo, Japan.; Saito E; Institute for Global Health Policy Research, National Center for Global Health and Medicine, Tokyo, Japan.; Gupta PC; Healis-Sekhsaria Institute for Public Health, Navi Mumbai, India.; Pednekar MS; Healis-Sekhsaria Institute for Public Health, Navi Mumbai, India.; Sawada N; Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Tsugane S; Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Graduate School of Public Health, International University of Health and Welfare, Tokyo, Japan.; Tamakoshi A; Department of Public Health, Hokkaido University Faculty of Medicine, Sapporo, Japan.; Kimura T; Department of Public Health, Hokkaido University Faculty of Medicine, Sapporo, Japan.; Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Gao YT; Department of Epidemiology, Shanghai Cancer Institute Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.; Koh WP; Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (ASTAR), Singapore, Singapore.; Cai H; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Sakata R; Radiation Effects Research Foundation, Hiroshima, Japan.; Tsuji I; Tohoku University Graduate School of Medicine, Sendai, Japan.; Malekzadeh R; Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Pourshams A; Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.; Kanemura S; Tohoku University Graduate School of Medicine, Sendai, Japan.; Kim J; Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, South Korea.; Chen Y; Department of Population Health and Environmental Medicine, New York University, New York, New York, USA.; Ito H; Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.; Division of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Oze I; Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.; Nagata C; Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.; Wada K; Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.; Sugawara Y; Department of Health Informatics and Public Health, Division of Epidemiology, Tohoku University Graduate School of Public Health, Sendai, Japan.; Park SK; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Shin A; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Cancer Research Institute, Seoul National University, Seoul, Republic of Korea.; Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Wang R; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Kweon SS; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.; Shin MH; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.; Poustchi H; Digestive Disease Research institute Tehran University of Medical Science, Tehran, Iran.; Vardanjani HM; MD-MPH Dual Degree Program, School of Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Science, Shiraz, Iran.; Ahsan H; Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.; Chia KS; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Matsuo K; Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Qiao YL; School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Rothman N; Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.; Zheng W; Division of Epidemiology, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Inoue M; Division of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan.; Kang D; Seoul National University College of Medicine, Seoul, Republic of Korea.; Boffetta P; Stony Brook Cancer Center, Stony Brook University, New York, New York, USA.; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Source
Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
Subject
Language
English
Abstract
There has been growing evidence suggesting that diabetes may be associated with increased liver cancer risk. However, studies conducted in Asian countries are limited. This project considered data of 968,738 adults pooled from 20 cohort studies of Asia Cohort Consortium to examine the association between baseline diabetes and liver cancer incidence and mortality. Cox proportional hazard model and competing risk approach was used for pooled data. Two-stage meta-analysis across studies was also done. There were 839,194 subjects with valid data regarding liver cancer incidence (5654 liver cancer cases [48.29/100,000 person-years]), follow-up time and baseline diabetes (44,781 with diabetes [5.3%]). There were 747,198 subjects with valid data regarding liver cancer mortality (5020 liver cancer deaths [44.03/100,000 person-years]), follow-up time and baseline diabetes (43,243 with diabetes [5.8%]). Hazard ratio (HR) (95% confidence interval [95%CI]) of liver cancer diagnosis in those with vs. without baseline diabetes was 1.97 (1.79, 2.16) (p < .0001) after adjusting for baseline age, gender, body mass index, tobacco smoking, alcohol use, and heterogeneity across studies (n = 586,072; events = 4620). Baseline diabetes was associated with increased cumulative incidence of death due to liver cancer (adjusted HR (95%CI) = 1.97 (1.79, 2.18); p < .0001) (n = 595,193; events = 4110). A two-stage meta-analytic approach showed similar results. This paper adds important population-based evidence to current literature regarding the increased incidence and mortality of liver cancer in adults with diabetes. The analysis of data pooled from 20 studies of different Asian countries and the meta-analysis across studies with large number of subjects makes the results robust.
(© 2024 UICC.)
(© 2024 UICC.)