학술논문
Oxidative stress and inflammation, two features associated with a high percentage body fat, and that may lead to diabetes mellitus and metabolic syndrome.
Document Type
Academic Journal
Author
Darroudi S; Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Fereydouni N; Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Tayefi M; Department of Cardiovascular, Imam Reza Hospital, Mashhad University of Medical Science (MUMS), Mashhad, Iran.; Head, University international Accreditation, International Office, Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.; Ahmadnezhad M; Nutrition research center, Department of Community Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.; Zamani P; Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Tayefi B; Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran.; Kharazmi J; Department of Biology, Mashhad Branch Islamic Azad University Mashhad, Iran.; Tavalaie S; Metabolic Syndrome research center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Heidari-Bakavoli A; Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Azarpajouh MR; Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, BN1 9PH, UK.; Ferns GA; Pharmaceutical Research Center, Pharmaceutical Institute Technology, Mashhad University of Medical Sciences, Mashhad, Iran.; Mohammadpour AH; Pharmaceutical Research Center, Pharmaceutical Institute Technology, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; Esmaily H; Social Determinants of Health Research, Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Ghayour-Mobarhan M; Metabolic Syndrome research center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Source
Publisher: Ios Press Country of Publication: Netherlands NLM ID: 8807441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8081 (Electronic) Linking ISSN: 09516433 NLM ISO Abbreviation: Biofactors Subsets: MEDLINE
Subject
Language
English
Abstract
Obesity is an important feature of the metabolic syndrome and is associated with an increased risk of type 2 diabetes mellitus, cardiovascular disease, and some cancers. The aim of this study was to determine the relationship between body fat percentage and an imbalance of the prooxidant/antioxidant balance (PAB), serum superoxide dismutase (SOD1) and inflammation (serum hs-CRP) and increase risk of metabolic syndrome and diabetes mellitus. In this study, 9154 individuals were recruited as part of the Mashhad Stroke and Heart Association Disorder (MASHAD) study. Subjects were categorized into two groups according to body fat percentage as defined >25% in male and > 30% in female, according to gender. Biochemical factors, including serum PAB, SOD1, and hs-CRP were measured in all subjects. SPSS version 18 was used for statistical analyses for all. GraphPad Prism 6 for figures was used. Of total number of subjects (9154), 6748 (73.7%) were found to have a high body fat (BF) percentage. Serum hs-CRP and PAB were significantly higher in individuals with a high BF percentage (P < 0.05) but SOD1 was not significantly different between the two groups (P > 0.05). BF percentage, serum PAB and serum hs-CRP were significantly higher in individuals with metabolic syndrome and diabetes versus those without metabolic syndrome and diabetes mellitus (P < 0.05), however serum SOD1 was significantly lower in individuals with metabolic syndrome (P < 0.005). Oxidative stress and inflammation are two factors that may link the presence of high BF percentage with the development of metabolic syndrome, diabetes, and cardiovascular disease. © 2018 BioFactors, 45(1):35-42, 2019.
(© 2018 International Union of Biochemistry and Molecular Biology.)
(© 2018 International Union of Biochemistry and Molecular Biology.)