학술논문
Infant fat mass and later child and adolescent health outcomes: a systematic review.
Document Type
Academic Journal
Author
Amati F; Department of Primary Care and Public Health, Imperial College London, London, UK f.amati@imperial.ac.uk.; McCann L; Centre for Primary Care, Wolfson Insitute of Population Health, Queen Mary University, London, UK.; Castañeda-Gutiérrez E; Health and Happiness Group, H&H Research, Geneva, Switzerland.; Prior E; Section of Neonatal Medicine, School of Public Health, Imperial College London, London, UK.; van Loo-Bouwman CA; Innovation, Yili Innovation Centre Europe, Yili Innovation Center Europe, Wageningen, The Netherlands.; Abrahamse-Berkeveld M; Department of Nutritional Physiology and Functional Nutrients, Danone Nutricia Research, Utrecht, The Netherlands.; Oliveros E; Abbott Nutrition Research and Development, Abbott Laboratories, Granada, Spain.; Ozanne S; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, UK.; Symonds ME; Centre for Perinatal Research, Academic Unit of Population and Lifespan Sciences, School of Medicine, University of Nottingham, Nottingham, UK.; Chang CY; International Life Science Institute, International Life Science Institute, European Branch, Brussels, Belgium.; Modi N; Section of Neonatal Medicine, School of Public Health, Imperial College London, London, UK.
Source
Publisher: BMJ Pub. Group [etc.] Country of Publication: England NLM ID: 0372434 Publication Model: Electronic Cited Medium: Internet ISSN: 1468-2044 (Electronic) Linking ISSN: 00039888 NLM ISO Abbreviation: Arch Dis Child Subsets: MEDLINE
Subject
Language
English
Abstract
Objective: Obesity and excess adiposity are leading causes of metabolic and cardiovascular morbidity and mortality. Early identification of individuals at risk is key for preventive strategies. We examined the relationship between infant body composition (0-2 years of age) and later (>2 years) health outcomes using a systematic review.
Design: We preregistered the study on PROSPERO (ID 288013) and searched Embase, PubMed and Cochrane databases for English language publications using the Medical Subject Headings (MeSH) terms 'infant' and 'body composition' and 'risk' between January 1946 and February 2022. We included studies which assessed infant body composition using predetermined in vivo methods other than body mass index (BMI).
Results: We identified 6015 articles. After abstract screening to assess eligibility, we reviewed 130 full text publications. 30 were included in the final assessment and narrative synthesis. Meta-analysis was not possible due to heterogeneity of results. All 30 studies were of high quality and reported associations between infant body composition and 19 different health outcomes after 2 years of age. Outcome measurements ranged from 2 years to 16 years. The strongest associations were found between infant fat mass and later fat mass (7 studies), and later BMI (5 studies). For 11 of the outcomes assessed, there was no relationship to infant adiposity detected.
Conclusions: Current evidence, from a small number of studies, suggests a positive association between infant adiposity and future adiposity or BMI, but the validity of infant body composition as a biomarker of future health remains inconclusive. Carefully designed, standardised studies are required to identify the value of infant body composition for predicting later health.
Trial Registration: PROSPERO: 288013.
Competing Interests: Competing interests: FA was paid an honoraria to complete the work. C-YC is a full-time employee of ILSI Europe.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Design: We preregistered the study on PROSPERO (ID 288013) and searched Embase, PubMed and Cochrane databases for English language publications using the Medical Subject Headings (MeSH) terms 'infant' and 'body composition' and 'risk' between January 1946 and February 2022. We included studies which assessed infant body composition using predetermined in vivo methods other than body mass index (BMI).
Results: We identified 6015 articles. After abstract screening to assess eligibility, we reviewed 130 full text publications. 30 were included in the final assessment and narrative synthesis. Meta-analysis was not possible due to heterogeneity of results. All 30 studies were of high quality and reported associations between infant body composition and 19 different health outcomes after 2 years of age. Outcome measurements ranged from 2 years to 16 years. The strongest associations were found between infant fat mass and later fat mass (7 studies), and later BMI (5 studies). For 11 of the outcomes assessed, there was no relationship to infant adiposity detected.
Conclusions: Current evidence, from a small number of studies, suggests a positive association between infant adiposity and future adiposity or BMI, but the validity of infant body composition as a biomarker of future health remains inconclusive. Carefully designed, standardised studies are required to identify the value of infant body composition for predicting later health.
Trial Registration: PROSPERO: 288013.
Competing Interests: Competing interests: FA was paid an honoraria to complete the work. C-YC is a full-time employee of ILSI Europe.
(© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)