학술논문
Histidine phosphorylation in bacterial chemotaxis.
Document Type
Theses
Author
Source
Dissertation Abstracts International; Dissertation Abstract International; 64-06B.
Subject
Language
English
Abstract
Summary: Hence, the phosphoaccepting histidine must exist in the normally unfavored Nδ1 H tautomeric state in order for CheA autophosphorylation to occur. The other two residues, Lys48 and His64, do not affect the reactivity of His45. Instead they contribute towards the structural integrity of the P1 active site. The results obtained in this thesis provide a solid structural and biochemical basis for further understanding the CheA phosphotransfer mechanism and may provide critical insight for the development of novel antibiotic agents.