학술논문

Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase.
Document Type
Article
Source
Mechanisms of Ageing & Development. Jun2014, Vol. 138, p53-58. 6p.
Subject
Life spans
Superoxide dismutase
Protein deficiency
Paraquat
Gene expression
Mitochondrial enzymes
Fungal genes
Yeast
Language
ISSN
0047-6374
Abstract
Highlights: [•] Yeast Nar1 deficiency results in shortened lifespan and sensitivity to paraquat. [•] Nar1 deficiency cells have decreased aconitase activity and lower SOD2 mRNA level. [•] Overexpression of SOD2 suppresses defects associated with Nar1-deficiency in yeast. [ABSTRACT FROM AUTHOR]