부산대학교 도서관

The leaves ofLippia javanicaare used for the treatment of several skin diseases in Ethiopia. Forty-two components were identified and quantified, by GC–MS and GC–FID, comprising 98.9% of the total oil withcis-sabinene hydrate (20.3%) and limonene (13.9%) as major components.cis-Sabinene hydrate is reported here for the first time as a constituent ofL. javanicaleaf oil (Ethiopia). The essential oil and its two fractions were assessed for their possible antimicrobial activities against two bacterial strains (Bacillus cereusandKlebsiella pneumoniae) and one fungal pathogen (Cryptococcus neoformans) using the disc diffusion method.K. pneumoniaewas found to be the most susceptible bacteria to the oxygenated fraction (MIC < 5 g/mL). The antioxidant property of the oil was assessed by free radical scavenging (DPPH) assay, with IC50= 16.6 L/mL. These findings may support the traditional uses of the plant for the treatment of skin diseases. [ABSTRACT FROM AUTHOR]