학술논문

Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: to treat or not to treat.
Document Type
Article
Source
Pan African Medical Journal. Jan-Apr2019, Vol. 32, p1-4. 4p.
Subject
*HIV infections
*HODGKIN'S disease
*HIV
*IMMUNOCOMPROMISED patients
*THERAPEUTICS
Language
ISSN
1937-8688
Abstract
Haemophagocytic lymphohistiocytosis (HLH) in Human Immunodeficiency Virus (HIV) infected individuals can either be due to the disease itself or due to associated infections/malignancies. The treatment for HLH requires immunosuppressive therapy but administering immunosuppressive therapy to an already immunosuppressed patient (HIV infection) is complex. We present two such cases of HLH in patients infected with HIV. In the first case, no alternate cause for HLH was found even after extensive investigations and it was attributed to the uncontrolled HIV replication. Patient was started on dexamethasone for the same but succumbed to hospital acquired pneumonia. The second patient was diagnosed with Hodgkin's lymphoma but he succumbed to his illness before initiating immunosuppressive therapy for HLH. We report these cases to highlight the dilemma and a need for further research in this direction. [ABSTRACT FROM AUTHOR]