학술논문
Liver Transplant: Adenosine Metabolism and Apoptosis.
Document Type
Article
Author
Source
Subject
*LIVER transplantation
*ADENOSINES
*APOPTOSIS
*NECROSIS
*TRANSPLANTATION of organs, tissues, etc.
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Language
ISSN
1525-7770
Abstract
Apoptosis and necrosis coexist in ischemia–reperfusion(I/R) injury following organ transplant. During experimental liver transplant we evidenced a deep alteration in energy and antioxidant status. The activity of purine catabolic enzymes was also altered. Caspase-3(C-3), protein tyrosine phosphatase(PTP) showed significative alterations that lead to DNA fragmentation. These findings could be of interest in new potential strategy to prevent and treat I/R injury. [ABSTRACT FROM AUTHOR]