부산대학교 도서관

Introduction: Physical inactivity and chronic myocardial injury, defined by elevation in high sensitivity cardiac troponin (Hs-Tn) levels, are important risk factors for HF in African Americans (AA). However, the inter-relationship between total physical activity levels (PA) and Hs-Tn levels for the risk of HF in AA is not well established. Hypothesis: The risk of HF will increase with decreasing PA and increasing hs-Tn levels among AA. Methods: We included 3,988 AA participants (36% male) from the Jackson Heart Study (JHS) free of prevalent HF at baseline. Total PA was assessed at baseline (2000-2003) using the previously validated self-reported survey. Hs-TnI levels were measured by the ARCHITECT assay platform (Abbott Diagnostics). Primary outcome of interest was incident HF hospitalization that was clinically adjudicated from 1/1/2005 onwards. Participants were stratified into 4 groups based on baseline PA levels [inactive (no PA) vs. active (PA levels >0)] and hs-TnI levels [low (<6 ng/L) vs. elevated (>6 ng/L)]. The risk of HF associated with different PA/hs-cTnI levels-based study groups was assessed using multivariable-adjusted Cox models that included age, sex, BMI, HTN, DM, systolic BP, renal function, and left ventricular hypertrophy. Results: Elevated hs-TnI levels were observed in 17% of study participants and 51.7% had some physical activity at baseline. There were 297 (7.4%) incident HF events (median follow-up 14yrs). In adjusted analysis, compared to the active participants with low hs-TnI levels, risk of HF was significantly higher among individuals with elevated hs-TnI levels across both PA strata and among inactive individuals across both hs-TnI strata (Table). The highest risk of HF was noted among inactive individuals with high hs-TnI levels (Table). The interaction between PA levels and hs-TnI for risk of HF was not significant (P interaction >0.10). Conclusions: The risk of HF associated with physical inactivity and high hs-Tn levels is cumulative and independent of each other among AA. The highest risk is seen among inactive individuals with elevated hs-TnI levels. Future studies are needed to determine if improving PA may modify the risk of HF among these high-risk individuals. [ABSTRACT FROM AUTHOR]