부산대학교 도서관

Summary: Background: To date, there are few studies that describe pharmacokinetics, safety and efficacy of posaconazole delayed‐release tablet (DRT) formulation in the paediatric population. Objectives: We evaluated retrospectively posaconazole plasma concentrations and safety of posaconazole DRT in paediatric haematology–oncology patients. Patients and methods: Posaconazole DRT was assessed in 28 haematological paediatric patients with a median age 15 of years (range 5‐18) and a median body weight of 50 kg (range 22‐83 kg). Twenty‐one patients received posaconazole DRT as prophylaxis and 7 patients as therapy. Results: As prophylaxis, the median daily dose was 5.5 mg/kg/day (range 2.2‐22.2) with posaconazole trough level ≥ 0.7 μg/mL in 80% by first week, 62.5% by second week and 87.5% by fourth week. As therapy, the median daily dose was 4 mg/kg/day (range 3.3‐4.5) with trough level ≥ 1 μg/mL 100% by first week, 80% by second week and 33.4% by fourth week. Conclusions: Posaconazole DRT is feasible in paediatric patients capable to swallow tablets. Specific pharmacokinetic studies are needed. [ABSTRACT FROM AUTHOR]