학술논문
The evaluation of genotoxic potential of ornidazole, nitroimidazole, in lymphocyte culture of patients with amebiasis.
Document Type
Article
Source
Subject
*GENETIC toxicology
*NITROIMIDAZOLES
*LYMPHOCYTES
*CELL culture
*AMEBIASIS
*CHROMOSOMES
*CARCINOGENICITY
*NUCLEOLUS
*PATIENTS
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Language
ISSN
0148-0545
Abstract
The genotoxicity study of ornidazole (ONZ) was carried out on human lymphocyte chromosomes, using sister chromatid exchange (SCE) and micronucleus (MN). Thirty-two patients with Entemoeba histolitica infection who received 1000 mg/day for 10 days were included in this study. SCE and MN were measured before and after therapy. A statistically significant increase was observed in the SCE ( P < 0.001) and MN frequencies ( P < 0.001) after ornidazole therapy. It was concluded that ONZ has a potential geno- and cytotoxic effect in human peripheral lymphocyte cultures. For this reason, further, detailed studies are needed to elucidate the ONZ mechanism of genotoxicity and its carcinogenic potential. [ABSTRACT FROM AUTHOR]