학술논문
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
Document Type
Article
Author
Dunlop, Malcolm G; Dobbins, Sara E; Farrington, Susan Mary; Jones, Angela M; Palles, Claire; Whiffin, Nicola; Tenesa, Albert; Spain, Sarah; Broderick, Peter; Ooi, Li-Yin; Domingo, Enric; Smillie, Claire; Henrion, Marc; Frampton, Matthew; Martin, Lynn; Grimes, Graeme; Gorman, Maggie; Semple, Colin; Ma, Yusanne P; Barclay, Ella
Source
Subject
*COLON cancer risk factors
*META-analysis
*GENOMES
*LOCUS (Genetics)
*DISEASE susceptibility
*CASE-control method
*HUMAN genetic variation
*
*
*
*
*
*
Language
ISSN
1061-4036
Abstract
We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10?10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10?10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10?10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC. [ABSTRACT FROM AUTHOR]