학술논문
Genes that mediate breast cancer metastasis to lung.
Document Type
Article
Author
Source
Subject
*GENES
*BREAST cancer
*METASTASIS
*LUNG diseases
*PROTEOMICS
*PATHOLOGY
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Language
ISSN
0028-0836
Abstract
By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis. [ABSTRACT FROM AUTHOR]