학술논문
Regulation of Mammalian Autophagy in Physiology and Pathophysiology.
Document Type
Article
Author
Ravikumar, Brinda; Sarkar, Sovan; Davies, Janet E.; Futter, Marie; Garcia-Arencibia, Moises; Green-Thompson, Zeyn W.; Jimenez-Sanchez, Maria; Korolchuk, Viktor I.; Lichtenberg, Maike; Shouqing Luo; Massey, Dunecan C. O.; Menzies, Fiona M.; Moreau, Kevin; Narayanan, Usha; Renna, Maurizio; Siddiql, Farah H.; Underwood, Benjamin R.; Winslow, Ashley R.; Rubinsztein, David C.
Source
Subject
*AUTOPHAGY
*PATHOLOGICAL physiology
*CYTOPLASM
*ORGANELLES
*HUMAN physiology
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Language
ISSN
0031-9333
Abstract
The article discusses the important role of mammalian autophagy in normal human physiology, health and disease. It states that autophagy, which is a highly conserved yeast to human is a major degradation process involving the clearance of long-lived protein and organelles. It mentions that autophagy is started by double membrane structure called autophagosomes engulfing in portions of cytoplasm. Meanwhile, autophagy upregulation will be regarded as a therapeutic approach for some human diseases.