학술논문
Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines.
Document Type
Article
Author
Source
Subject
*DIAZEPINES
*CONDENSATION
*ETHYLENEDIAMINE
*GUANIDINE
*CANCER cells
*CELL lines
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Language
ISSN
1475-6366
Abstract
Novel substituted 5,7-diaryl-2,3-dihydro-1,4-diazepines and 4,6-diaryl-2-aminopyrimidines were synthesized and tested for their antiproliferative activity. Title compounds were obtained by cyclocondensation of a substituted flavone with ethylenediamine and guanidine respectively. The cytotoxicity in vitro against various human leukemic cancer cell lines viz., Jurkat, HL60, MOLT3, NCEB-1, K562 was determined. [ABSTRACT FROM AUTHOR]