학술논문
Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P2 –P1 cyclopropyl alanine combination for improved potency
Document Type
Article
Author
Source
Subject
*HEPATITIS C
*AMINO acids
*LIVER diseases
*VIRAL hepatitis
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Language
ISSN
0960-894X
Abstract
Abstract: Modification of the P2 and P1 side chains of earlier P3-capped α-ketoamide inhibitor of HCV NS3 serine protease 1 resulted in the discovery of compound 24 with about 10-fold improvement in potency. [Copyright &y& Elsevier]