학술논문
Synthesis of C‐Aryl Glycosides via Ru‐Catalyzed Remote C−H Glycosylation of 8‐Aminoquinoline Amides.
Document Type
Article
Author
Source
Subject
*GLYCOSYLATION
*AMIDES
*FREE radicals
*RUTHENIUM catalysts
*FUNCTIONAL groups
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Language
ISSN
1615-4150
Abstract
C‐Aryl glycoside is a class of structural motifs with important medicinal value. Herein, a remote C−H glycosylation strategy enabled by Ruthenium(II)‐catalyzed with mostly α‐stereoselectivity is described. This approach exhibits great functional group compatibility with various glycosides and arylamides. A series of experiments provided strong evidence for the free radical mechanism and reversible C−H activation process, and a possible mechanism was proposed. [ABSTRACT FROM AUTHOR]