학술논문
The potential of cardiac allografts from donors after cardiac death at the University of Wisconsin Organ Procurement Organization
Document Type
Article
Source
Subject
*HEART transplantation
*ORGAN donors
*HEART disease related mortality
*HYPOXEMIA
*RETROSPECTIVE studies
*ISCHEMIA
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*
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Language
ISSN
1010-7940
Abstract
Abstract: Objective: The purpose of this study is to investigate the potential availability of hearts from adult donation after cardiac death (DCD) donors within an acceptable hypoxic period. Methods: We retrospectively reviewed a donor database from the University of Wisconsin Organ Procurement Organization Donor Tracking System between 2004 and 2006. The DCD population (n =78) was screened using our inclusion criteria for DCD cardiac donor suitability, including warm ischaemic time (WIT) limit of 30min. In the same period, 70 hearts were donated from brain-dead donors. Results: Of 78 DCD donors, 12 (15%) met our proposed DCD cardiac donor criteria. The mean WIT of these 12 DCD donors was 21min (range 14–29min). When inclusion criteria are further narrowed to (1) age <30 years, (2) WIT <20min and (3) male gender, only two out of 12 met the criteria. Conclusions: Based on our proposed DCD cardiac donor criteria, the potential application of DCD cardiac donors would represent an increase in cardiac donation of 17% (12/70) during the 3-year period. When the criteria were narrowed to the initial ‘ideal’ case, only two donors met such criteria, suggesting that such ‘ideal’ DCD donors are rare but they do exist. [Copyright &y& Elsevier]