부산대학교 도서관

L5262 --> Cardiovascular disease is the leading cause of death in the United States of America, being responsible for 610,000 deaths annually. One in seven of which are related to Ischemic Heart Disease (IHD). Collateral growth is found to be vital to cardiovascular health, with those who have poor collateral networks having a more difficult time recovering and are more likely to have a recurring problem than those with healthy collateral networks. In this study, we investigate if GDF11 affects these collateral networks. To further investigate this, we will use the GDF11 deficient mice and wild type control mice. GDF11 is controversial in its function in aging. However, our study is more focused on the function of GDF11 in coronary collateral growth. We will compare the coronary collaterals among the following groups: 1) naïve wild type and Gdf 11 knockout mice without any intervention; 2) wild type and Gdf 11 knockout mice whose left anterior descending artery (LAD) had been ligated, to mimic a myocardial infarction; 3) wild type and Gdf 11 knockout mice with repetitive ischemia stimulation. Microfil and micro‐CT will be used to measure the coronary collaterals and contrast echocardiograph will be used to measure the coronary blood flow. These structure and function data will demonstrate the role of GDF 11 in coronary collateral growth. [ABSTRACT FROM AUTHOR]