학술논문
Accurate Prediction of the Stage of Histological Chorioamnionitis before Delivery by Amniotic Fluid IL-8 Level.
Document Type
Article
Author
Source
Subject
*AMNIOTIC liquid
*INTERLEUKIN-8
*CESAREAN section
*C-reactive protein
*LEUKOCYTE count
*REPRODUCTIVE immunology
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Language
ISSN
1046-7408
Abstract
Objective To estimate the stage of histological chorioamnionitis (h- CAM) antenatally using clinical data. Materials and methods Four hundred and twenty-eight singleton mothers were recruited. Clinical data including the levels of white blood cell count ( WBC), C-reactive protein ( CRP), amniotic fluid interleukin-8 ( AF- IL-8) at Cesarean section, and maternal body temperature ( MBT) were collected. Results Histological chorioamnionitis was present in 45.3% of the cases. Poor neonatal prognosis was highest (59.1%) in cases with h- CAM stage III. AF- IL-8 (odds ratio: 8.5, 95% CI: 5.1-14.8, P < 0.0001) and MBT (odds ratio: 2.3, 95% CI: 1.13-4.1, P = 0.0192) were independent risk factors for h- CAM. The cutoff value of AF- IL-8 for predicting each stage of h- CAM (stage I or higher, stage II or higher, and stage III) were ≥9.9 ng/mL, ≥17.3 ng/mL, and ≥55.9 ng/mL, respectively. Conclusion The stage of h- CAM was able to be predicted accurately by the level of AF- IL-8 before delivery. [ABSTRACT FROM AUTHOR]