학술논문
An eltrombopag‐induced remission of bone‐marrow aplasia accompanied by marked leukoerythroblastosis and splenomegaly.
Document Type
Article
Author
Source
Subject
*PURE red cell aplasia
*SOMATIC mutation
*BONE marrow cells
*ERYTHROCYTES
*HEMATOPOIETIC stem cells
*EXTRAMEDULLARY hematopoiesis
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Language
ISSN
0007-1048
Abstract
An eltrombopag-induced remission of bone-marrow aplasia accompanied by marked leukoerythroblastosis and splenomegaly Bone-marrow (BM) failure is caused by various mechanisms, including immune destruction of haematopoietic stem progenitor cells (HSPCs) and intrinsic abnormalities of these cells.1 Although pancytopenia with fatty BM is a sign suggestive of aplastic anaemia (AA), benign BM failure such as AA is commonly ruled out when leukoerythroblastosis is evident in the peripheral blood (PB). This study reports the clinical courses of two recently experienced cases [a 25-year-old woman (Case 1) and a 45-year-old-man (Case 2)] of BM failure, experiencing severe BM aplasia that was associated with marked leukoerythroblastosis in the PB and mild hepatosplenomegaly; a sustained remission of the atypical BM failure was induced by eltrombopag in Case 1. [Extracted from the article]