학술논문
A census of human cancer genes.
Document Type
Article
Author
Source
Subject
*CANCER research
*ONCOGENES
*CANCER genetics
*GENETIC mutation
*CANCER cells
*BIOLOGICAL variation
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Language
ISSN
1474-175X
Abstract
A central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis ('cancer genes'). After two decades of searching, how many have been identified and how do they compare to the complete gene set that has been revealed by the human genome sequence? We have conducted a 'census' of cancer genes that indicates that mutations in more than 1% of genes contribute to human cancer. The census illustrates striking features in the types of sequence alteration, cancer classes in which oncogenic mutations have been identified and protein domains that are encoded by cancer genes. [ABSTRACT FROM AUTHOR]